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Case Report

Three Cases of Lymphocytic Infiltration of the Eyelid

1
Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan
2
Department of Oncologic Pathology, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan
3
Department of Dermatology, Matsusaka City Hospital, Matsusaka, Mie 515-8544, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Gürkan Kaya
Received: 6 April 2021 / Revised: 30 April 2021 / Accepted: 3 May 2021 / Published: 8 May 2021
Lymphocytic infiltration of the skin (LIS), first reported by Jessner and Kanof in 1953, is a disease of unknown etiology characterized by erythematous papules and plaques on the head, neck, and upper back and histopathological findings of a normal epidermis with underlying lymphocytic infiltration of the reticular dermis without mucin deposition. A 69-year-old man and a 21-year-old woman presented with edematous indurative erythema of the left upper eyelid. Lymphocytic infiltration of the dermis with CD4+ T cell predominance was noted on biopsy. A 68-year-old man presented with a four-year history of recurrent edematous indurative erythema of the right upper eyelid that extended up to the right cheek. Predominantly dermal infiltration of CD8+ T lymphocytes was found on biopsy. We treated all three patients with 8–16 mg of methylprednisolone daily, and the erythema and induration improved. CD4+ T cells were predominant in the acute phase (patients 1 and 2), whereas CD8+ T cells were predominant in the chronic phase (patient 3). CD8+ T cells may be involved in LIS recurrence. Lymphocytic infiltration of the eyelid may be associated with isolated circumscribed, edematous, indurative, colorless lesions that are responsive to daily low-to-middle doses of oral methylprednisolone. View Full-Text
Keywords: lymphocytic infiltration of the skin; methylprednisolone; CD4+ T cell; CD8+ T cell; lymphocytic infiltration of the eyelid lymphocytic infiltration of the skin; methylprednisolone; CD4+ T cell; CD8+ T cell; lymphocytic infiltration of the eyelid
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MDPI and ACS Style

Sugioka, K.; Hayashi, A.; Ichishi, M.; Sugimoto, Y.; Habe, K.; Yamanaka, K. Three Cases of Lymphocytic Infiltration of the Eyelid. Dermatopathology 2021, 8, 124-129. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020018

AMA Style

Sugioka K, Hayashi A, Ichishi M, Sugimoto Y, Habe K, Yamanaka K. Three Cases of Lymphocytic Infiltration of the Eyelid. Dermatopathology. 2021; 8(2):124-129. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020018

Chicago/Turabian Style

Sugioka, Kyoko, Akinobu Hayashi, Masako Ichishi, Yasuko Sugimoto, Koji Habe, and Keiichi Yamanaka. 2021. "Three Cases of Lymphocytic Infiltration of the Eyelid" Dermatopathology 8, no. 2: 124-129. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020018

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