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TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

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Ophthalmology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain
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Pathology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain
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Plastic Surgery Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain
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Pathology Department, Hospital José Molina Orosa, 35500 Arrecife, Spain
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Dermatology Department, Hospital José Molina Orosa, 35500 Arrecife, Spain
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Human Anatomy and Histology Department, Universidad de Salamanca, 37007 Salamanca, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Gürkan Kaya
Received: 1 March 2021 / Revised: 19 May 2021 / Accepted: 22 May 2021 / Published: 25 May 2021
(This article belongs to the Section Molecular Dermatopathology)
Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on TP53 and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheath where TC develop, a MMR, a p53 expression assessment and a TP53 study were performed in a series of 5 PTT cases, including a giant one. We failed to demonstrate a MMR disorder on studied PTT, but we agree with previous results suggesting increased p53 expression in these tumours, particularly in proliferative areas. TP53 alteration was confirmed with FISH technique, demonstrating TP53 deletion in most cells. View Full-Text
Keywords: trichilemmal cyst; proliferating trichilemmal tumor; MMR; TP53; p53 trichilemmal cyst; proliferating trichilemmal tumor; MMR; TP53; p53
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MDPI and ACS Style

Martín-Sanz, R.; Sayagués, J.M.; García-Cano, P.; Azcue-Mayorga, M.; Parra-Pérez, M.d.C.; Pacios-Pacios, M.Á.; Piqué-Durán, E.; Feito, J. TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours. Dermatopathology 2021, 8, 147-158. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020021

AMA Style

Martín-Sanz R, Sayagués JM, García-Cano P, Azcue-Mayorga M, Parra-Pérez MdC, Pacios-Pacios MÁ, Piqué-Durán E, Feito J. TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours. Dermatopathology. 2021; 8(2):147-158. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020021

Chicago/Turabian Style

Martín-Sanz, Raquel, José M. Sayagués, Pilar García-Cano, Mikel Azcue-Mayorga, María d.C. Parra-Pérez, María Á. Pacios-Pacios, Enric Piqué-Durán, and Jorge Feito. 2021. "TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours" Dermatopathology 8, no. 2: 147-158. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020021

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