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Concurrent Adjacent Merkel Cell Carcinoma and Chronic Lymphocytic Leukemia without Simultaneous Merkel Cell Polyomavirus Detection: A Case Series

1
Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, USA
2
Department of Dermatology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77004, USA
*
Author to whom correspondence should be addressed.
Current Address: Department of Pathology and Laboratory Medicine, Stanford University, Stanford, CA 94305, USA.
Academic Editor: Gürkan Kaya
Received: 4 May 2021 / Revised: 3 June 2021 / Accepted: 5 June 2021 / Published: 7 June 2021
(This article belongs to the Section Molecular Dermatopathology)
Background: The association between Merkel cell carcinoma (MCC) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL) is well established in the literature. A majority of MCCs are known to be associated with Merkel cell carcinoma polyomavirus (MCPyV), which is postulated to be a possible causative agent linking these two entities. We aim to identify the presence of MCPyV in patients with concurrent adjacent MCC and CLL/SLL. Methods: Archived pathology materials of three cutaneous or surgical excisions with concurrent MCC and CLL/SLL were reviewed. Additional 12-µm sections from paraffin-embedded tissue of these resections were matched with original hematoxylin and eosin-stained slides and used to extract foci from each tumor separately. DNA was extracted from these tissues, and polymerase chain reaction (PCR), utilizing a primer set within a highly conserved “small T” viral DNA region, was done to detect MCPyV. Results: Out of 140 cases of cutaneous or surgical excisions with MCC identified in our electronic medical records (EMR), three had coexisting neighboring CLL/SLL in the same resection specimen. In one case out of three, MCPyV was detected in MCC but not in CLL/SLL. The remaining two cases showed no detection of MCPyV in either MCC or CLL/SLL. Conclusion: MCPyV was not concurrently associated with adjacent MCC and CLL/SLL, indicating that it is not driving simultaneous tumorigenesis, at least in a subset of these cases. View Full-Text
Keywords: Merkel cell carcinoma; CLL/SLL; Merkel cell polyomavirus; concurrent tumorigenesis Merkel cell carcinoma; CLL/SLL; Merkel cell polyomavirus; concurrent tumorigenesis
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MDPI and ACS Style

Saade, R.; Najjar, S.; Arslan, M.E.; Rady, P.; Tyring, S.K.; Nazeer, T. Concurrent Adjacent Merkel Cell Carcinoma and Chronic Lymphocytic Leukemia without Simultaneous Merkel Cell Polyomavirus Detection: A Case Series. Dermatopathology 2021, 8, 190-201. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020025

AMA Style

Saade R, Najjar S, Arslan ME, Rady P, Tyring SK, Nazeer T. Concurrent Adjacent Merkel Cell Carcinoma and Chronic Lymphocytic Leukemia without Simultaneous Merkel Cell Polyomavirus Detection: A Case Series. Dermatopathology. 2021; 8(2):190-201. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020025

Chicago/Turabian Style

Saade, Rayan, Saleh Najjar, Mustafa E. Arslan, Peter Rady, Stephen K. Tyring, and Tipu Nazeer. 2021. "Concurrent Adjacent Merkel Cell Carcinoma and Chronic Lymphocytic Leukemia without Simultaneous Merkel Cell Polyomavirus Detection: A Case Series" Dermatopathology 8, no. 2: 190-201. https://0-doi-org.brum.beds.ac.uk/10.3390/dermatopathology8020025

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