Next Article in Journal
Copper Isotope Compositions of Superoxide Dismutase and Metallothionein from Post-Mortem Human Frontal Cortex
Next Article in Special Issue
Concise Review of Nickel Human Health Toxicology and Ecotoxicology
Previous Article in Journal / Special Issue
Nickel-Induced Oligomerization of the Histidine-Rich Metallochaperone CooJ from Rhodospirillum Rubrum
Open AccessReview

The Maturation Pathway of Nickel Urease

School of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong 999077, China
Author to whom correspondence should be addressed.
Received: 7 June 2019 / Revised: 28 June 2019 / Accepted: 4 July 2019 / Published: 6 July 2019
(This article belongs to the Special Issue Bioinorganic Chemistry of Nickel)
Maturation of urease involves post-translational insertion of nickel ions to form an active site with a carbamylated lysine ligand and is assisted by urease accessory proteins UreD, UreE, UreF and UreG. Here, we review our current understandings on how these urease accessory proteins facilitate the urease maturation. The urease maturation pathway involves the transfer of Ni2+ from UreE → UreG → UreF/UreD → urease. To avoid the release of the toxic metal to the cytoplasm, Ni2+ is transferred from one urease accessory protein to another through specific protein–protein interactions. One central theme depicts the role of guanosine triphosphate (GTP) binding/hydrolysis in regulating the binding/release of nickel ions and the formation of the protein complexes. The urease and [NiFe]-hydrogenase maturation pathways cross-talk with each other as UreE receives Ni2+ from hydrogenase maturation factor HypA. Finally, the druggability of the urease maturation pathway is reviewed. View Full-Text
Keywords: urease maturation; metallochaperone; nickel; G-protein; conformational change urease maturation; metallochaperone; nickel; G-protein; conformational change
Show Figures

Figure 1

MDPI and ACS Style

Nim, Y.S.; Wong, K.-B. The Maturation Pathway of Nickel Urease. Inorganics 2019, 7, 85.

AMA Style

Nim YS, Wong K-B. The Maturation Pathway of Nickel Urease. Inorganics. 2019; 7(7):85.

Chicago/Turabian Style

Nim, Yap S.; Wong, Kam-Bo. 2019. "The Maturation Pathway of Nickel Urease" Inorganics 7, no. 7: 85.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop