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Vanadium(V) Complexes with Siderophore Vitamin E-Hydroxylamino-Triazine Ligands

Department of Chemistry, University of Cyprus, Nicosia 2901, Cyprus
Department of Agricultural Production, Biotechnology and Food Science, Cyprus University of Technology, Limassol 3036, Cyprus
Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Authors to whom correspondence should be addressed.
Academic Editor: Dinorah Gambino
Received: 21 July 2021 / Revised: 25 September 2021 / Accepted: 27 September 2021 / Published: 29 September 2021
Novel vitamin E chelate siderophore derivatives and their VV and FeIII complexes have been synthesised and the chemical and biological properties have been evaluated. In particular, the α- and δ-tocopherol derivatives with bis-methyldroxylamino triazine (α-tocTHMA) and (δ-tocDPA) as well their VV complexes, [V2VO3(α-tocTHMA)2] and [V2IVO3(δ-tocTHMA)2], have been synthesised and characterised by infrared (IR), nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and ultra violet-visible (UV-Vis) spectroscopies. The dimeric vanadium complexes in solution are in equilibrium with their respefrctive monomers, H2O + [V2VO2(μ-O)]4+ = 2 [VVO(OH)]2+. The two amphiphilic vanadium complexes exhibit enhanced hydrolytic stability. EPR shows that the complexes in lipophilic matrix are mild radical initiators. Evaluation of their biological activity shows that the compounds do not exhibit any significant cytotoxicity to cells. View Full-Text
Keywords: vanadium; vitamin E; EPR; tocopherol; 51V NMR vanadium; vitamin E; EPR; tocopherol; 51V NMR
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MDPI and ACS Style

Loizou, M.; Hadjiadamou, I.; Drouza, C.; Keramidas, A.D.; Simos, Y.V.; Peschos, D. Vanadium(V) Complexes with Siderophore Vitamin E-Hydroxylamino-Triazine Ligands. Inorganics 2021, 9, 73.

AMA Style

Loizou M, Hadjiadamou I, Drouza C, Keramidas AD, Simos YV, Peschos D. Vanadium(V) Complexes with Siderophore Vitamin E-Hydroxylamino-Triazine Ligands. Inorganics. 2021; 9(10):73.

Chicago/Turabian Style

Loizou, Maria, Ioanna Hadjiadamou, Chryssoula Drouza, Anastasios D. Keramidas, Yannis V. Simos, and Dimitrios Peschos. 2021. "Vanadium(V) Complexes with Siderophore Vitamin E-Hydroxylamino-Triazine Ligands" Inorganics 9, no. 10: 73.

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