Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species
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Research Centre for Crystalline Materials, School of Medical and Life Sciences, Sunway University, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
2
Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
*
Authors to whom correspondence should be addressed.
Academic Editor: Graeme Hogarth
Inorganics 2021, 9(6), 48; https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics9060048
Received: 30 April 2021
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Revised: 24 May 2021
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Accepted: 10 June 2021
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Published: 14 June 2021
(This article belongs to the Special Issue Metal Dithiocarbamate Complexes: Versatile Ligands in Coordination Chemistry with Applications in Medicine, Materials Science, and Beyond)
Bacterial infection remains a worldwide problem that requires urgent addressing. Overuse and poor disposal of antibacterial agents abet the emergence of bacterial resistance mechanisms. There is a clear need for new approaches for the development of antibacterial therapeutics. Herein, the antibacterial potential of molecules based on dithiocarbamate anions, of general formula R(R’)NCS2(−), and metal salts of transition metals and main group elements, is summarized. Preclinical studies show a broad range of antibacterial potential, and these investigations are supported by appraisals of possible biological targets and mechanisms of action to guide chemical syntheses. This bibliographic review of the literature points to the exciting potential of dithiocarbamate-based therapeutics in the crucial battle against bacteria. Additionally, included in this overview, for the sake of completeness, is mention of the far fewer studies on the antifungal potential of dithiocarbamates and even less work conducted on antiparasitic behavior.
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Keywords:
antibacterial therapeutics; antifungal activity; dithiocarbamate; metal dithiocarbamates; sulfur compounds; metal-based drugs; mechanism of action
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MDPI and ACS Style
Yeo, C.I.; Tiekink, E.R.T.; Chew, J. Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species. Inorganics 2021, 9, 48. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics9060048
AMA Style
Yeo CI, Tiekink ERT, Chew J. Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species. Inorganics. 2021; 9(6):48. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics9060048
Chicago/Turabian StyleYeo, Chien I., Edward R.T. Tiekink, and Jactty Chew. 2021. "Insights into the Antimicrobial Potential of Dithiocarbamate Anions and Metal-Based Species" Inorganics 9, no. 6: 48. https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics9060048
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