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Article

Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque

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Department of Neuroscience and Biomedical Engineering, Aalto University, 12200 Espoo, Finland
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Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
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Department of Oral Diseases, Karolinska Institutet, 14152 Huddinge, Sweden
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Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland
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Faculty of Medicine, Department of Pharmacology, University of Helsinki, 00290 Helsinki, Finland
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Department of Congenital Heart Surgery and Organ Transplantation, New Children’s Hospital, University of Helsinki, 00290 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Andrea Pilloni
Received: 28 February 2021 / Revised: 19 April 2021 / Accepted: 28 April 2021 / Published: 3 May 2021
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
Aim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque. Methods: Fifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm2 of 810 nm LED light was applied to the aPDT-treatment area. Plaque area and gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) were measured, and plaque bacteriomes before and after the study were analyzed using 16S rRNA sequencing. Results: aPDT administration was preformed successfully and plaque-specifically with the combination of ICG and the applicator. Total plaque area and endpoint MMP-8 levels were reduced on the aPDT-treatment side. aPDT reduced Streptococcus, Acinetobacteria, Capnocytophaga, and Rothia bacteria species in plaques. Conclusion: ICG-assisted aPDT reduces plaque forming bacteria and exerts anti-inflammatory and anti-proteolytic effects. View Full-Text
Keywords: antibacterial photodynamic therapy; dental plaque; gingivitis antibacterial photodynamic therapy; dental plaque; gingivitis
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MDPI and ACS Style

Nikinmaa, S.; Moilanen, N.; Sorsa, T.; Rantala, J.; Alapulli, H.; Kotiranta, A.; Auvinen, P.; Kankuri, E.; Meurman, J.H.; Pätilä, T. Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque. Dent. J. 2021, 9, 52. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9050052

AMA Style

Nikinmaa S, Moilanen N, Sorsa T, Rantala J, Alapulli H, Kotiranta A, Auvinen P, Kankuri E, Meurman JH, Pätilä T. Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque. Dentistry Journal. 2021; 9(5):52. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9050052

Chicago/Turabian Style

Nikinmaa, Sakari, Niina Moilanen, Timo Sorsa, Juha Rantala, Heikki Alapulli, Anja Kotiranta, Petri Auvinen, Esko Kankuri, Jukka H. Meurman, and Tommi Pätilä. 2021. "Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque" Dentistry Journal 9, no. 5: 52. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9050052

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