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Review

Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review

Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, Baronissi, 84081 Salerno, Italy
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Academic Editor: Daniele Botticelli
Received: 31 July 2021 / Revised: 29 August 2021 / Accepted: 2 September 2021 / Published: 4 September 2021
Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn, acts as a contributory factor in periodontitis development. Periodontitis has been associated with benign tumors and cancers and withseveral disorders, including hyperlipidemia. Correspondingly, periodontal treatment may exert a positive effect on lipid metabolism, although opposite evidence has also been reported. As a counterpart, the therapy for hyperlipidemia, conventionally based on statins, has been proposed to positively affect periodontal conditions, mainly due to statin pleiotropic effects, reducing periodontal inflammation and promoting osseointegration. Therefore, the present systematic review aimed to evaluate, in subjects with untreated periodontitis and peri-implant disease (Population), the effect of routine systemically administered statins (Intervention), compared to non-statin use (Comparison), on periodontal parameters around natural teeth and implants (Outcome). Discordant results were found in periodontal parameters, and the current lack of such data related to peri-implant tissues and to alveolar bone loss highlights the need for further studies on the topic, potentially paving the way for a more comprehensive approach to periodontitis and peri-implantitis management. Indeed, the validation of the beneficial effect provided by systemically delivered statins on periodontal and peri-implant tissues may direct recall scheduling, predict response to therapy and, therefore, guide treatment strategies of periodontal and peri-implant treatments in statin users. View Full-Text
Keywords: periodontitis; peri-implantitis; statins; simvastatin; hyperlipidemia; periodontal disease periodontitis; peri-implantitis; statins; simvastatin; hyperlipidemia; periodontal disease
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MDPI and ACS Style

Di Spirito, F.; Schiavo, L.; Pilone, V.; Lanza, A.; Sbordone, L.; D’Ambrosio, F. Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review. Dent. J. 2021, 9, 100. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9090100

AMA Style

Di Spirito F, Schiavo L, Pilone V, Lanza A, Sbordone L, D’Ambrosio F. Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review. Dentistry Journal. 2021; 9(9):100. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9090100

Chicago/Turabian Style

Di Spirito, Federica, Luigi Schiavo, Vincenzo Pilone, Antonio Lanza, Ludovico Sbordone, and Francesco D’Ambrosio. 2021. "Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review" Dentistry Journal 9, no. 9: 100. https://0-doi-org.brum.beds.ac.uk/10.3390/dj9090100

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