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Targeting Aberrant Sialylation to Treat Cancer

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK
Author to whom correspondence should be addressed.
Received: 20 September 2019 / Accepted: 10 October 2019 / Published: 13 October 2019
(This article belongs to the Special Issue Application of Glycobiology in the Treatment of Diseases)
Cell surface carbohydrates (known as glycans) are often aberrantly expressed or found at atypical levels in cancer. Glycans can impact all steps in tumour progression, from malignant transformation to metastasis, and have roles in all the cancer hallmarks. An increased understanding of glycans in the metastatic cascade offers exciting new therapeutic opportunities. Glycan-based targeting strategies are currently being tested in clinical trials and are a rich and untapped frontier for development. As we learn more about cancer glycobiology, new targets will continue to emerge for drug design. One key change in tumour glycosylation is the upregulation of cancer-associated sialylated glycans. Abnormal sialylation is integral to tumour growth, metastasis and immune evasion; therefore, targeting sialic acid moieties in cancer could be of high therapeutic value. Here, we summarise the changes to sialic acid biology in cancer and discuss recent advances and technologies bringing sialic-acid targeting treatments to the forefront of cancer therapeutics. View Full-Text
Keywords: glycosylation; glycans; cancer; sialic acid; sialylation; immunotherapy; therapeutics glycosylation; glycans; cancer; sialic acid; sialylation; immunotherapy; therapeutics
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MDPI and ACS Style

Munkley, J.; Scott, E. Targeting Aberrant Sialylation to Treat Cancer. Medicines 2019, 6, 102.

AMA Style

Munkley J, Scott E. Targeting Aberrant Sialylation to Treat Cancer. Medicines. 2019; 6(4):102.

Chicago/Turabian Style

Munkley, Jennifer, and Emma Scott. 2019. "Targeting Aberrant Sialylation to Treat Cancer" Medicines 6, no. 4: 102.

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