Next Article in Journal
Correction: Oral Intake of Royal Jelly Has Protective Effects against Tyrosine Kinase Inhibitor-Induced Toxicity in Patients with Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled Trial. Medicines, 2019, 6, 2
Previous Article in Journal
Cocculus hirsutus (L.) W.Theob. (Menispermaceae): A Review on Traditional Uses, Phytochemistry and Pharmacological Activities
Article

Hospital-Acquired Serum Ionized Calcium Derangements and Their Associations with In-Hospital Mortality

1
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Internal Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA 17101, USA
3
Division of Pulmonary and Pulmonary Critical Care Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
4
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
5
Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, USA
6
Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA
7
Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
8
Division of Pulmonary, Critical Care and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
*
Authors to whom correspondence should be addressed.
Received: 18 October 2020 / Revised: 9 November 2020 / Accepted: 17 November 2020 / Published: 19 November 2020
Background: The objective of this study was to report the incidence of in-hospital serum ionized calcium derangement and its impact on mortality. Methods: We included 12,599 non-dialytic adult patients hospitalized at a tertiary medical center from January 2009 to December 2013 with normal serum ionized calcium at admission and at least 2 in-hospital serum ionized calcium values. Using serum ionized calcium of 4.60–5.40 mg/dL as the normal reference range, in-hospital serum ionized calcium levels were categorized based on the presence of hypocalcemia and hypercalcemia in hospital. We performed logistic regression to assess the relationship of in-hospital serum ionized calcium derangement with mortality. Results: Fifty-four percent of patients developed new serum ionized calcium derangements: 42% had in-hospital hypocalcemia only, 4% had in-hospital hypercalcemia only, and 8% had both in-hospital hypocalcemia and hypercalcemia. In-hospital hypocalcemia only (OR 1.28; 95% CI 1.01–1.64), in-hospital hypercalcemia only (OR 1.64; 95% CI 1.02–2.68), and both in-hospital hypocalcemia and hypercalcemia (OR 1.73; 95% CI 1.14–2.62) were all significantly associated with increased in-hospital mortality, compared with persistently normal serum ionized calcium levels. Conclusions: In-hospital serum ionized calcium derangements affect more than half of hospitalized patients and are associated with increased in-hospital mortality. View Full-Text
Keywords: hypercalcemia; hypocalcemia; calcium; electrolytes; mortality; hospitalization hypercalcemia; hypocalcemia; calcium; electrolytes; mortality; hospitalization
Show Figures

Figure 1

MDPI and ACS Style

Thongprayoon, C.; Hansrivijit, P.; Petnak, T.; Mao, M.A.; Bathini, T.; Vallabhajosyula, S.; Lertjitbanjong, P.; Qureshi, F.; Erickson, S.B.; Cheungpasitporn, W. Hospital-Acquired Serum Ionized Calcium Derangements and Their Associations with In-Hospital Mortality. Medicines 2020, 7, 70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7110070

AMA Style

Thongprayoon C, Hansrivijit P, Petnak T, Mao MA, Bathini T, Vallabhajosyula S, Lertjitbanjong P, Qureshi F, Erickson SB, Cheungpasitporn W. Hospital-Acquired Serum Ionized Calcium Derangements and Their Associations with In-Hospital Mortality. Medicines. 2020; 7(11):70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7110070

Chicago/Turabian Style

Thongprayoon, Charat, Panupong Hansrivijit, Tananchai Petnak, Michael A. Mao, Tarun Bathini, Saraschandra Vallabhajosyula, Ploypin Lertjitbanjong, Fawad Qureshi, Stephen B. Erickson, and Wisit Cheungpasitporn. 2020. "Hospital-Acquired Serum Ionized Calcium Derangements and Their Associations with In-Hospital Mortality" Medicines 7, no. 11: 70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7110070

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop