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Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “Yokukansan” in Rats with Acute Inflammatory Pain

1
Department of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan
2
Department of Anesthesiology, St. Luke’s International Hospital, Tokyo 104-8560, Japan
3
Department of Palliative Medicine, Showa University Yokohama Northern Hospital, Kanagawa 224-8503, Japan
4
Pharmaceutical Department, Showa University Hospital, Tokyo 142-8666, Japan
*
Author to whom correspondence should be addressed.
Received: 12 November 2020 / Revised: 14 December 2020 / Accepted: 15 December 2020 / Published: 17 December 2020
Background: Fentanyl can induce acute opioid tolerance and postoperative hyperalgesia when administered at a single high dose; thus, this study examined the analgesic efficacy of a combination of fentanyl and Yokukansan (YKS). Methods: Rats were divided into control, formalin-injected (FOR), YKS-treated+FOR (YKS), fentanyl-treated+FOR (FEN), and YKS+FEN+FOR (YKS+FEN) groups. Acute pain was induced via subcutaneous injection of formalin into the paw. The time engaged in pain-related behavior was measured. Results: In the early (0–10 min) and intermediate (10–20 min) phases, pain-related behavior in the YKS+FEN group was significantly inhibited compared with the FOR group. In the late phase (20–60 min), pain-related behavior in the FEN group was the longest and significantly increased compared with the YKS group. We explored the influence on the extracellular signal-regulated kinase (ERK) pathway in the spinal cord, and YKS suppressed the phosphorylated ERK expression, which may be related to the analgesic effect of YKS in the late phase. Conclusions: These findings suggest that YKS could reduce the use of fentanyl and combined use of YKS and fentanyl is considered clinically useful. View Full-Text
Keywords: Yokukansan; fentanyl; transient receptor potential ankyrin 1 (TRPA1) channel; phosphorylated extracellular signal-regulated kinase (pERK); whole-cell patch-clamp recording; herbal medicine Yokukansan; fentanyl; transient receptor potential ankyrin 1 (TRPA1) channel; phosphorylated extracellular signal-regulated kinase (pERK); whole-cell patch-clamp recording; herbal medicine
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MDPI and ACS Style

Akanuma, Y.; Kato, M.; Takayama, Y.; Ikemoto, H.; Adachi, N.; Ohashi, Y.; Yogi, W.; Okumo, T.; Tsukada, M.; Sunagawa, M. Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “Yokukansan” in Rats with Acute Inflammatory Pain. Medicines 2020, 7, 75. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7120075

AMA Style

Akanuma Y, Kato M, Takayama Y, Ikemoto H, Adachi N, Ohashi Y, Yogi W, Okumo T, Tsukada M, Sunagawa M. Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “Yokukansan” in Rats with Acute Inflammatory Pain. Medicines. 2020; 7(12):75. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7120075

Chicago/Turabian Style

Akanuma, Yuko; Kato, Mami; Takayama, Yasunori; Ikemoto, Hideshi; Adachi, Naoki; Ohashi, Yusuke; Yogi, Wakako; Okumo, Takayuki; Tsukada, Mana; Sunagawa, Masataka. 2020. "Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine “Yokukansan” in Rats with Acute Inflammatory Pain" Medicines 7, no. 12: 75. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7120075

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