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Review

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

1
Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
2
Department of Physical Education, Faculty of Education, The Mico University College, 1A Marescaux Road, Kingston 5, Jamaica
3
Department of Biotechnology, Faculty of Science and Technology, The University of the West Indies, Kingston 7, Jamaica
4
Department of Basic Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
5
School of Allied Health and Wellness, College of Health Sciences, University of Technology, Kingston 7, Jamaica
*
Author to whom correspondence should be addressed.
Received: 1 July 2020 / Revised: 29 July 2020 / Accepted: 9 August 2020 / Published: 14 August 2020
Background: Breast cancer is one of the principal causes of death among women and there is a pressing need to develop novel and effective anti-cancer agents. Natural plant products have shown promising results as anti-cancer agents. Their effectiveness is reported as decreased toxicity in usage, along with safety and less recurrent resistances compared with hormonal targeting anti-cancer agents. Methods: A literature search was conducted for all English-language literature published prior to June 2020. The search was conducted using electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library. The search strategy included keywords such as breast cancer, herbs, anti-cancer biologically active components, clinical research, chemotherapy drugs amongst others. Results: The literature provides documented evidence of the chemo-preventative and chemotherapeutic properties of Ginseng, garlic (Allium sativum), Black cohosh (Actaea racemose), Tumeric (Curcuma longa), Camellia sinenis (green tea), Echinacea, Arctium (burdock), Flaxseed (Linum usitatissimum) and Black Cumin (Nigella sativa). Conclusions: The nine herbs displayed anti-cancer properties and their outcomes and mechanisms of action include inhibition of cell proliferation, angiogenesis and apoptosis as well as modulation of key intracellular pathways. However, more clinical trials and cohort human studies should be conducted to provide key evidence of their medical benefits. View Full-Text
Keywords: breast cancer; herbs; mechanism; action; anti-cancer; chemotherapy; drugs breast cancer; herbs; mechanism; action; anti-cancer; chemotherapy; drugs
MDPI and ACS Style

McGrowder, D.A.; Miller, F.G.; Nwokocha, C.R.; Anderson, M.S.; Wilson-Clarke, C.; Vaz, K.; Anderson-Jackson, L.; Brown, J. Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action. Medicines 2020, 7, 47. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7080047

AMA Style

McGrowder DA, Miller FG, Nwokocha CR, Anderson MS, Wilson-Clarke C, Vaz K, Anderson-Jackson L, Brown J. Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action. Medicines. 2020; 7(8):47. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7080047

Chicago/Turabian Style

McGrowder, Donovan A., Fabian G. Miller, Chukwuemeka R. Nwokocha, Melisa S. Anderson, Cameil Wilson-Clarke, Kurt Vaz, Lennox Anderson-Jackson, and Jabari Brown. 2020. "Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action" Medicines 7, no. 8: 47. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7080047

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