Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
Abstract
:1. Introduction
1.1. H. pylori Infection and Gastric Cancer
1.2. Subpopulation Variance of H. pylori and Gastric Cancer
2. Materials and Methods
2.1. Study Design
2.2. Design Rationale
2.3. QES Significance and Relevance
2.4. QES Dynamism and Intervention Mapping
2.5. Search Engine and Strategies
2.6. Study Eligibility
2.7. Data Extraction
2.8. Study Variables
2.9. Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author & Date | Sample Population | Sample Size (Exposure) | Variables Studied | Measure of Effect | Results |
---|---|---|---|---|---|
Chang et al., 2001 [42] | 136 GC, 13 controls | 126 exposed, 146 unexposed | Age, sex, marital status, occupation, education, salary, H. pylori serology | OR 1.82, (1.10–3.00) | + effect |
Cho et al., 2010 [43] | 2819 GC, 564 controls | 2763 exposed, 618 unexposed | Age, sex, smoking, drinking, family history, living conditions, education, SES, family structure | OR 3.13, (2.46–3.97) | + effect |
Eom et al., 2016 [44] | 846 GC, 846 controls | 1252 exposed, 440 unexposed | Age, sex, smoking, drinking, education, BMI, H. pylori infection, cagA | OR 1.43, (1.12–1.81) | + effect |
Gong et al., 2013 [45] | 327 GC, 327 controls | 448 exposed, 169 unexposed | Age, sex, BMI, H. pylori serology, family history, smoking, drinking | OR 2.93, (1.88–4.59) | + effect |
Gwack et al., 2006 [46] | 100 GC, 400 controls | 449 exposed, 51 unexposed | Age, sex, smoking, drinking, education, diagnosis, H. pylori serology, cagA and vacA | OR 0.96, (0.68–1.36) | N/A |
Kim et al., 2012 [47] | 829 GC, 270 controls | 917 exposed, 180 unexposed | Age, sex, smoking, drinking, family history, BMI, H. pylori serology, eradication efforts, past diagnoses | GCC, OR 2.50, (1.78–3.52) GNCC, OR 2.10, (0.98–4.48) | + effect |
Kim et al., 1997 [48] | 160 GC, 160 controls | 179 exposed, 141 unexposed | Age, sex, H. pylori serology | OR 1.39, (0.89–2.17) | + effect |
Kim et al., 2000 [49] | 287 GC, 33 controls | 142 exposed, 178 unexposed | Age, sex, urbanity, SES, education, BMI, H. pylori serology, smoking, drinking | 43.9% GC group, 48.5% non-GC group | N/A |
Kim et al., 2005 [50] | 295 GC, 295 controls | N/A | Age, sex, SES, education, BMI, H. pylori serology, smoking, drinking, family history | OR 1.68, (1.14–2.44) | + effect |
Kim et al., 2018 [51] | 415 GC, 830 controls | 868 exposed, 353 unexposed | Age, sex, BMI, H. pylori serology, family history, smoking, drinking, exercise, education, marital status, occupation, salary, diagnoses | 92.1% GC 58.6% non-GC | + effect |
Kim et al., 2015 [52] | 998 GC, 1288 controls | 1817 exposed, 469 unexposed | Age, sex, BMI, smoking, drinking, family history, H. pylori serology, diagnosis | M: 86.2% GC M: 77.1% non-GC W: 87.2% GC W: 71.1% non-GC | + effect |
Woo et al., 2014 [53] | 334 GC, 334 controls | 457 exposed, 211 unexposed | Age, sex, BMI, H. pylori serology, family history, smoking, drinking, exercise, education, marital status, occupation | 84.4% GC 52.4% non-GC | + effect |
Yang et al., 2017 [54] | 450 GC, 1050 controls | 1051 exposed, 449 unexposed | Age, ALDH2 genotype, drinking, smoking, education, salary, diet, H. pylori serology, family history | OR 7.07, (4.60–10.86) | + effect |
Author & Date | Sample Population | Sample Size (Expose) | Variables Studied | Measure of Effect | Results |
---|---|---|---|---|---|
Fernandez de Larrea-Baz et al., 2017 [55] | 264 GC, 2071 controls | 2017 exposed, 259 unexposed | Age, sex, race, education, SES, BMI, smoking, family history, diagnosis | OR 1.31, (0.82–2.11) | + effect |
Garcia-Gonzalez et al., 2015 [56] | 603 GC, 675 controls | 794 exposed, 484 unexposed | Age, sex, smoking, family history, cagA vagA | OR 1.39, (1.10–1.76) | + effect |
Garcia-Gonzalez et al., 2007 [57] | 404 GC, 404 controls | 506 exposed, 302 unexposed | Age, sex, smoking, family history, cagA vagA | OR 1.46, (1.08–1.97) | + effect |
Author and Publishing Year | ES (OR) | 95% CI | Weight | |
---|---|---|---|---|
South Korea (Asia) | ||||
Chang, W.K. et al. (2001) | 1.60 | 1.01 | 2.53 | 4.65 |
Cho, S.J. et al. (2010) | 3.13 | 2.46 | 3.97 | 4.67 |
Eom, S.Y. et al. (2016) | 1.41 | 1.14 | 1.76 | 6.42 |
Gong, E.J. et al. (2013) | 3.03 | 2.05 | 4.48 | 3.06 |
Gwack, J.Y. et al. (2006) | 0.99 | 0.71 | 1.38 | 6.34 |
Kim, J.Y. et al. (2012) | 2.50 | 1.78 | 3.52 | 4.21 |
Kim, H.Y. et al. (1997) | 1.39 | 0.89 | 2.17 | 5.14 |
Kim, Y.S. et al. (2000) | 0.91 | 0.46 | 1.83 | 4.95 |
Kim, D.S. et al. (2005) | 1.68 | 1.14 | 2.44 | 5.10 |
Kim, J.H. et al. (2018) | 1.57 | 1.31 | 1.89 | 6.48 |
Kim, H.J. et al. (2015) | 0.57 | 0.50 | 0.66 | 6.91 |
Lee, S.A. et al. (2003) | 1.18 | 0.77 | 1.80 | 5.66 |
Woo, H.D. et al. (2014) | 1.61 | 1.26 | 2.07 | 6.09 |
Yang, S. et al. (2017) | 1.48 | 1.25 | 1.75 | 6.60 |
Sub-Total D + L Pooled ES | 1.56 | 1.19 | 1.94 | 76.29 |
Spain (Western Europe) | ||||
Fernandez de Larrea-Baz, N. et al. (2017) | 1.05 | 0.87 | 1.26 | 6.73 |
Garcia-Gonzalez, M.A. et al. (2015) | 1.39 | 1.10 | 1.76 | 6.36 |
Garcia-Gonzalez, M.A. et al. (2007) | 1.46 | 1.08 | 1.97 | 5.94 |
Palli, D. et al. (2006) | 1.07 | 0.56 | 2.06 | 4.69 |
Sub-Total D + L Pooled ES | 1.23 | 1.00 | 1.45 | 23.71 |
Overall D + L Pooled ES | 1.47 | 1.19 | 1.76 | 100.00 |
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Holmes, L., Jr.; Rios, J.; Berice, B.; Benson, J.; Bafford, N.; Parson, K.; Halloran, D. Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis. Medicines 2021, 8, 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001
Holmes L Jr., Rios J, Berice B, Benson J, Bafford N, Parson K, Halloran D. Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis. Medicines. 2021; 8(1):1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001
Chicago/Turabian StyleHolmes, Laurens, Jr., Jasmine Rios, Betyna Berice, Jacqueline Benson, Nastocia Bafford, Kadedrah Parson, and Daniel Halloran. 2021. "Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis" Medicines 8, no. 1: 1. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8010001