Next Article in Journal
Lignosulfonate Rapidly Inactivates Human Immunodeficiency and Herpes Simplex Viruses
Next Article in Special Issue
COVID-19 Infection and Neuropathological Features
Previous Article in Journal
Ethics in Medicines: Exposing Unethical Practices and Corruption in All Sectors of Medicines Is Essential for Improving Global Public Health and Saving Patients’ Lives
Previous Article in Special Issue
Coronavirus Disease 2019 (COVID-19) Crisis Measures: Health Protective Properties?
Opinion

Autoimmune Disorders & COVID-19

1
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil
2
Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil
3
Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil
4
Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21044-020, Brazil
*
Authors to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: William Cho
Received: 25 August 2021 / Revised: 21 September 2021 / Accepted: 26 September 2021 / Published: 28 September 2021
Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm. Since 2019, several studies regarding the interplay between autoimmune diseases and COVID-19 infections is increasing all over the world. In addition, thanks to new scientific findings, we actually know better why certain conditions are considered a higher risk in both situations. There are instances when having an autoimmune disease increases susceptibility to COVID-19 complications, such as when autoantibodies capable of neutralizing type I IFN are present, and other situations in which having COVID-19 infection precedes the appearance of various autoimmune and autoinflammatory diseases, including multisystem inflammatory syndrome in children (MIS-C), Guillain-Barré syndrome, and Autoimmune haemolytic anaemia (AIHA), thus, adding to the growing mystery surrounding the SARS-CoV-2 virus and raising questions about the nature of its link with autoimmune and autoinflammatory sequelae. Herein, we discuss the role of host and virus genetics and some possible immunological mechanisms that might lead to the disease aggravation. View Full-Text
Keywords: coronavirus disease 19; autoimmunity; viral infections; immune system coronavirus disease 19; autoimmunity; viral infections; immune system
MDPI and ACS Style

Freire-de-Lima, L.; Scovino, A.M.; Barreto Menezes, C.C.; Marques da Fonseca, L.; Santos dos Reis, J.; Rodrigues da Costa Santos, M.A.; Monteiro da Costa, K.; Antonio do Nascimento Santos, C.; Freire-de-Lima, C.G.; Morrot, A. Autoimmune Disorders & COVID-19. Medicines 2021, 8, 55. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8100055

AMA Style

Freire-de-Lima L, Scovino AM, Barreto Menezes CC, Marques da Fonseca L, Santos dos Reis J, Rodrigues da Costa Santos MA, Monteiro da Costa K, Antonio do Nascimento Santos C, Freire-de-Lima CG, Morrot A. Autoimmune Disorders & COVID-19. Medicines. 2021; 8(10):55. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8100055

Chicago/Turabian Style

Freire-de-Lima, Leonardo, Aline M. Scovino, Camilla C. Barreto Menezes, Leonardo Marques da Fonseca, Jhenifer Santos dos Reis, Marcos A. Rodrigues da Costa Santos, Kelli Monteiro da Costa, Carlos Antonio do Nascimento Santos, Celio G. Freire-de-Lima, and Alexandre Morrot. 2021. "Autoimmune Disorders & COVID-19" Medicines 8, no. 10: 55. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8100055

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop