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Article

The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats

1
Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso P.M.B 4000, Oyo State, Nigeria
2
Department of Medical Biochemistry, Osun State University, Osogbo P.M.B 4494, Osun State, Nigeria
3
Department of Science Laboratory and Technology, Faculty of Pure of Applied Sciences, Ladoke Akintola University of Technology, Ogbomoso P.M.B 4000, Oyo State, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editor: Basil D. Roufogalis
Received: 21 April 2021 / Revised: 11 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals, which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Out of the total fifty male Wistar rats obtained, fifteen were used for acute toxicity study, while the remaining thirty-five were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat chow (NRC) and 16% high salt diet (HSD) only, respectively. Animals in groups 3, 4 and 5 were fed 16% HSD with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE), respectively, once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. Poly-herbal extract (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentrations and also increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high-salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats. View Full-Text
Keywords: sodium chloride; poly-herbal; antioxidants; lipid profile; liver; kidney; aorta sodium chloride; poly-herbal; antioxidants; lipid profile; liver; kidney; aorta
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MDPI and ACS Style

Olorunnisola, O.S.; Adegbola, P.I.; Ajilore, B.S.; Akintola, O.A.; Fadahunsi, O.S. The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats. Medicines 2021, 8, 25. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060025

AMA Style

Olorunnisola OS, Adegbola PI, Ajilore BS, Akintola OA, Fadahunsi OS. The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats. Medicines. 2021; 8(6):25. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060025

Chicago/Turabian Style

Olorunnisola, Olubukola S., Peter I. Adegbola, Bamidele S. Ajilore, Olayemi A. Akintola, and Olumide S. Fadahunsi 2021. "The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats" Medicines 8, no. 6: 25. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060025

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