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The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective

Molecular Medicine, NSW Health Pathology, John Hunter Hospital, Newcastle, NSW 2305, Australia
Academic Editors: Achinto Saha and William Cho
Received: 30 March 2021 / Revised: 31 May 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)
Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms of the cell biology of regulation and homeostasis, which could explain the timeline of evolutionary cancer biology as degenerative, inflammatory and neoplasm progressions in these multifactorial and heterogeneous prostatic diseases. Results: This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment. Conclusions: An understanding of these biological processes of prostate ageing can provide potential strategies for early prevention and could contribute to maintaining quality of life for the ageing individual along with substantial medical cost savings. View Full-Text
Keywords: benign prostatic hyperplasia; prostate cancer; testosterone aging; vascular aging; inflamm-aging; amyloidosis; autophagy; tumorigenesis; prostate stagnation; endothelial dysfunction; inflammation; nitric oxide; oxidative stress; testosterone replacement therapy; aging benign prostatic hyperplasia; prostate cancer; testosterone aging; vascular aging; inflamm-aging; amyloidosis; autophagy; tumorigenesis; prostate stagnation; endothelial dysfunction; inflammation; nitric oxide; oxidative stress; testosterone replacement therapy; aging
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MDPI and ACS Style

Phua, T.J. The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective. Medicines 2021, 8, 30. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060030

AMA Style

Phua TJ. The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective. Medicines. 2021; 8(6):30. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060030

Chicago/Turabian Style

Phua, Teow J. 2021. "The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective" Medicines 8, no. 6: 30. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8060030

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