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Communication

Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells

1
Laboratory of Nutri-Pharmacotherapeutics Management, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama 350-0295, Japan
2
Laboratory of Pharmacognocy, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1, Keyakidai, Sakado, Saitama 350-0295, Japan
3
Laboratory of Biological Chemistry, Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
4
Research and Development, Morinda Worldwide, Inc., 3-2-2 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: William Cho
Received: 13 July 2021 / Revised: 31 July 2021 / Accepted: 2 August 2021 / Published: 4 August 2021
Leaves of Morinda citrifolia (noni) have been used in Polynesian folk medicine for the treatment of pain and inflammation, and their juice is very popular worldwide as a functional food supplement. This study aimed to demonstrate that M. citrifolia seed extract exerts anti-inflammatory effects on RAW264 cells stimulated by lipopolysaccharide. To confirm the inhibitory effect of M. citrifolia seed extract, we assessed the production of nitric oxide (NO) and inflammatory cytokines. The M. citrifolia seed extract showed a significant inhibition of NO production, with no effect on cell viability, and was more active than M. citrifolia seed oil, leaf extract, and fruit extract. The M. citrifolia seed extract was found to reduce the expression of inducible NO synthase and tumor necrosis factor-alpha of pro-inflammatory cytokines. These results suggest that the anti-inflammatory effect of M. citrifolia seed extract is related to a reduction in the expression of inflammatory mediators and support its potential therapeutic use. View Full-Text
Keywords: morinda citrifolia; noni seeds; NO production; anti-inflammation; RAW264 cells morinda citrifolia; noni seeds; NO production; anti-inflammation; RAW264 cells
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MDPI and ACS Style

Tanikawa, T.; Kitamura, M.; Hayashi, Y.; Tomida, N.; Uwaya, A.; Isami, F.; Inoue, Y. Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells. Medicines 2021, 8, 43. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8080043

AMA Style

Tanikawa T, Kitamura M, Hayashi Y, Tomida N, Uwaya A, Isami F, Inoue Y. Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells. Medicines. 2021; 8(8):43. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8080043

Chicago/Turabian Style

Tanikawa, Takashi, Masashi Kitamura, Yasuhiro Hayashi, Natsumi Tomida, Akemi Uwaya, Fumiyuki Isami, and Yutaka Inoue. 2021. "Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells" Medicines 8, no. 8: 43. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8080043

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