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Article

Prospective Comparison of 24-Hour Urine Creatinine Clearance with Estimated Glomerular Filtration Rates in Chronic Renal Disease Patients of African Descent

1
Department of Pathology, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
2
Department of Medicine, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
*
Author to whom correspondence should be addressed.
Academic Editor: Guy Rostoker
Received: 18 June 2021 / Revised: 17 August 2021 / Accepted: 30 August 2021 / Published: 1 September 2021
(This article belongs to the Special Issue Early Diagnosis and Public Health and Ethics Issues)
Background: The 24-hour (24-h) creatinine clearance (CrCl) is the most common method for measuring GFR in clinical laboratories. However, the limitations of CrCl have resulted in the widespread acceptance of mathematically derived estimated glomerular filtration rate (eGFR) using Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in predicting eGFR. The aim of the study was to compare 24-h CrCl with eGFR derived from these formulae and to identify which could be the best alternative. Method: A prospective study was conducted involving 140 CKD patients. Creatinine and cystatin C concentrations were determined using the cobas 6000 analyzer. The eGFR was calculated using the CG formula, 4-variable MDRD and CKD-EPI equations, and Bland-Alman plots bias was determined. Results: The CG and MDRD formulas had mean eGFR values similar to CrCl and correlation coefficients (r) were highest for CG (0.906) and lowest for MDRD (0.799). The CG equation was in agreement with 24-h CrCl in all but stage V CKD while the MDRD equation compared well in all except Stage IV CKD. The CG equation was positively biased (0.9857) while the MDRD had a negative bias (−0.05). Conclusion: The Cockcroft-Gault formula provides a more accurate assessment of GFR than 24-h CrCl and would be recommended as a substitute to provide the best estimate of GFR in our population. View Full-Text
Keywords: glomerular; filtration; rate; creatinine; estimate; cystatin C; kidney; disease; chronic glomerular; filtration; rate; creatinine; estimate; cystatin C; kidney; disease; chronic
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MDPI and ACS Style

Tapper, M.; McGrowder, D.A.; Dilworth, L.; Soyibo, A. Prospective Comparison of 24-Hour Urine Creatinine Clearance with Estimated Glomerular Filtration Rates in Chronic Renal Disease Patients of African Descent. Medicines 2021, 8, 48. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8090048

AMA Style

Tapper M, McGrowder DA, Dilworth L, Soyibo A. Prospective Comparison of 24-Hour Urine Creatinine Clearance with Estimated Glomerular Filtration Rates in Chronic Renal Disease Patients of African Descent. Medicines. 2021; 8(9):48. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8090048

Chicago/Turabian Style

Tapper, Marlene, Donovan A. McGrowder, Lowell Dilworth, and Adedamola Soyibo. 2021. "Prospective Comparison of 24-Hour Urine Creatinine Clearance with Estimated Glomerular Filtration Rates in Chronic Renal Disease Patients of African Descent" Medicines 8, no. 9: 48. https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8090048

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