Bioengineering, Volume 8, Issue 1 (January 2021) – 14 articles
Cover Story (view full-size image): The use of electrospun fibers for neural repair is advantageous since fibers can be fabricated to mimic the native nervous system extracellular matrix and provide contact guidance for infiltrating glia and regenerating axons. The various characteristics of electrospun fibers, such as fiber alignment, diameter, surface nanotopography, surface chemistry, and therapeutic delivery, can be modified to achieve a desired glial cell response to injury. Here, we show that changing the diameter of aligned electrospun fibers can enhance the uniaxial elongation of glia, which is shown to improve glial-cell-mediated neurite extension. View this paper
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