Bioengineering, Volume 8, Issue 2 (February 2021) – 16 articles
Cover Story (view full-size image): Collagen fiber formation is essential to human health. Over the last decade, there has been growing evidence that collagen fiber organization is not only a structural scaffold for normal tissue function, but, in some instances, it correlates with cancer onset and progression. In this review, we focus on the published evidence showing that fibrillar collagen organization and structure is an important factor and potential candidate biomarker in disease etiology and progression in a wide variety of cancers. We review the literature pertaining to collagen morphology in diagnosis, patient prognosis, and treatment response in many cancer types. View this paper
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