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Review

Potential Safety Issues Surrounding the Use of Benzoate Preservatives

Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Received: 19 February 2018 / Revised: 9 March 2018 / Accepted: 5 April 2018 / Published: 11 April 2018
(This article belongs to the Special Issue Beverages Additives)
Sodium benzoate (E211) and potassium sorbate (E202) have long been used for large-scale beverage preservation, yet it is potassium sorbate that is now the preferred option for most soft drink manufacturers. Partly this is a reaction to the discovery that benzoate can cause drinks to contain traces of the carcinogen benzene. This benzene is thought to have its origins in a free-radical catalysed reaction of the benzoate with ascorbic acid. However, there may be additional benefits to using potassium sorbate rather than the benzoate preservatives in beverages. In children, a high dietary intake of sodium benzoate may be associated with asthma, allergy, or attention deficit–hyperactivity disorder. Benzoate is now known to influence cognitive functioning. By acting as a competitive inhibitor of the enzyme D-amino acid oxidase (DAAO), thereby reducing the DAAO-catalysed degradation of D-serine, it can upregulate the activity of the N-methyl-d-aspartate receptors in the brain. A high benzoate intake might also generate glycine deficiency, lack of glycine generally exerting a negative impact on brain neurochemistry. There are therefore strong grounds for suspecting that dietary benzoate can have neuromodulatory (mood, learning, and personality) effects and influence child hyperactivity disorders. View Full-Text
Keywords: preservatives; sodium benzoate; potassium sorbate; hippuric acid; benzene; urea cycle disorder therapy; cognitive functioning; hypoglycinemia preservatives; sodium benzoate; potassium sorbate; hippuric acid; benzene; urea cycle disorder therapy; cognitive functioning; hypoglycinemia
MDPI and ACS Style

Piper, P.W. Potential Safety Issues Surrounding the Use of Benzoate Preservatives. Beverages 2018, 4, 33. https://0-doi-org.brum.beds.ac.uk/10.3390/beverages4020033

AMA Style

Piper PW. Potential Safety Issues Surrounding the Use of Benzoate Preservatives. Beverages. 2018; 4(2):33. https://0-doi-org.brum.beds.ac.uk/10.3390/beverages4020033

Chicago/Turabian Style

Piper, Peter W. 2018. "Potential Safety Issues Surrounding the Use of Benzoate Preservatives" Beverages 4, no. 2: 33. https://0-doi-org.brum.beds.ac.uk/10.3390/beverages4020033

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