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Drugs, Active Ingredients and Diseases Database in Spanish. Augmenting the Resources for Analyses on Drug–Illness Interactions

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Unidad Interdisciplinaria en Ingeniería y Tecnologías Avanzadas, Instituto Politécnico Nacional, Av. IPN No. 2580, L. Ticomán, Ciudad de México 07340, Mexico
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Tecnológico Nacional de México, Tecnológico de Estudios Superiores de Ixtapaluca, Km. 7 Carretera Ixtapaluca-Coatepec S/N San Juan, Ixtapaluca, Estado de México 56580, Mexico
*
Author to whom correspondence should be addressed.
Received: 8 November 2020 / Revised: 18 December 2020 / Accepted: 4 January 2021 / Published: 9 January 2021
(This article belongs to the Section Chemoinformatics)
Quantitative and qualitative data on active-ingredient drug composition are essential information for characterizing near-field exposure of consumers to product-related chemicals, among other things. Equally as important is the characterization of the relationship between one or many active ingredients in terms of the diseases they are prescribed for. Such evaluations, however, require quantitative information at different anatomical levels. To complement the available sources of information on active substances and diseases, we have designed a database with enough versatility to potentially be used in a variety of analyzes. By using information provided by a well-established online pharmacological dictionary, we present a database with 11 tables which are easy to access and manipulate. Specifically, we present datasets containing the details of 12,827 marketed drug products, 40,164 diseases, 6231 active pharmaceutical ingredients and 4093 side effects. We exemplify the usefulness of our database with three simple visualizations, which confirm the importance of the data for quantifying the complexity in the associations among active substances, diseases and side effects. Although there are databases with detailed information on active substances and diseases, none of them can be found in Spanish. Our work presents an option that contributes substantially to obtaining well classified information in order to evaluate the roles of active pharmaceutical ingredients, diseases and side effects. These datasets also provide information about clinical and pharmacological groupings which may be useful for clinical and academic researchers. The database will be regularly updated and extended with the newly available Virtual Medicinal Products. View Full-Text
Keywords: drug–disease classification; drug–disease interaction; pharmacological database drug–disease classification; drug–disease interaction; pharmacological database
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MDPI and ACS Style

López-Rodríguez, I.; Reyes-Manzano, C.F.; Reyes-Ramírez, I.; Contreras-Uribe, T.J.; Guzmán-Vargas, L. Drugs, Active Ingredients and Diseases Database in Spanish. Augmenting the Resources for Analyses on Drug–Illness Interactions. Data 2021, 6, 3. https://0-doi-org.brum.beds.ac.uk/10.3390/data6010003

AMA Style

López-Rodríguez I, Reyes-Manzano CF, Reyes-Ramírez I, Contreras-Uribe TJ, Guzmán-Vargas L. Drugs, Active Ingredients and Diseases Database in Spanish. Augmenting the Resources for Analyses on Drug–Illness Interactions. Data. 2021; 6(1):3. https://0-doi-org.brum.beds.ac.uk/10.3390/data6010003

Chicago/Turabian Style

López-Rodríguez, Irene; Reyes-Manzano, César F.; Reyes-Ramírez, Israel; Contreras-Uribe, Tania J.; Guzmán-Vargas, Lev. 2021. "Drugs, Active Ingredients and Diseases Database in Spanish. Augmenting the Resources for Analyses on Drug–Illness Interactions" Data 6, no. 1: 3. https://0-doi-org.brum.beds.ac.uk/10.3390/data6010003

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