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Review

Effects of Statins on Renin–Angiotensin System

1
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran
2
Department of Internal Diseases, School of Medicine, University Hospital Center Zagreb, Zagreb University, 10000 Zagreb, Croatia
3
Quchan Branch, Department of Food Science and Technology, Islamic Azad University, Quchan 9479176135, Iran
4
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
5
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy
6
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
7
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
8
School of Medicine, The University of Western Australia, Perth 6009, Australia
9
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
*
Author to whom correspondence should be addressed.
Equally contributed.
J. Cardiovasc. Dev. Dis. 2021, 8(7), 80; https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd8070080
Received: 19 May 2021 / Revised: 2 July 2021 / Accepted: 5 July 2021 / Published: 9 July 2021
Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested. View Full-Text
Keywords: statins; renin–angiotensin system (RAS); hypertension statins; renin–angiotensin system (RAS); hypertension
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MDPI and ACS Style

Kiaie, N.; Gorabi, A.M.; Reiner, Ž.; Jamialahmadi, T.; Ruscica, M.; Sahebkar, A. Effects of Statins on Renin–Angiotensin System. J. Cardiovasc. Dev. Dis. 2021, 8, 80. https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd8070080

AMA Style

Kiaie N, Gorabi AM, Reiner Ž, Jamialahmadi T, Ruscica M, Sahebkar A. Effects of Statins on Renin–Angiotensin System. Journal of Cardiovascular Development and Disease. 2021; 8(7):80. https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd8070080

Chicago/Turabian Style

Kiaie, Nasim, Armita M. Gorabi, Željko Reiner, Tannaz Jamialahmadi, Massimiliano Ruscica, and Amirhossein Sahebkar. 2021. "Effects of Statins on Renin–Angiotensin System" Journal of Cardiovascular Development and Disease 8, no. 7: 80. https://0-doi-org.brum.beds.ac.uk/10.3390/jcdd8070080

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