J. Fungi, Volume 7, Issue 2 (February 2021) – 92 articles
Cover Story (view full-size image): This review explains in a simplified way the information published in recent years on the immune response to the emerging fungi Scedosporium/Lomentospora. Fungal cell wall components, including peptidorhamnomannans, α-glucans and glucosylceramides, are involved in immune response activation following their recognition by TLR2, TLR4 and Dectin-1. After that, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells against these fungi are species-specific. Furthermore, to evade host immune response, these fungi use different evasion mechanisms, including inducing host non-protective response, masking fungal molecular patterns and destructing host defense proteins. However, many aspects remain to be elucidated, and more research is necessary to shed light on the immune response to these fungi. View this paper
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