Gels, Volume 6, Issue 4 (December 2020) – 19 articles
Cover Story (view full-size image): Graphene oxide (GO)-reinforced oleogels of cocoa butter (CB; oleogelator) and rice bran oil (RBO; liquid phase) were developed as ophthalmic drug delivery systems. The inclusion of GO within the CB-RBO oleogel considerably altered the microstructure of the prepared oleogels. GO-loaded oleogels showed significant enhancements in the crystalline nature, elasticity, and stress-bearing properties. Moreover, the crystallization process of CB in the oleogels was delayed in the presence of GO. Both X-ray diffraction and thermal studies confirmed the crystallization of CB in stable β’ and β polymorphic forms in each of the oleogels. It was observed that the inclusion of GO within the oleogels could increase the ex-vivo corneal permeation of the model drug (ciprofloxacin HCl) across the corneal tissue. View this paper
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