Non-Coding RNA, Volume 6, Issue 4 (December 2020) – 10 articles
Cover Story (view full-size image): Long non-coding RNAs (lncRNAs) are defined as non-protein coding transcripts with a minimal length of 200 nucleotides. They are involved in physiological processes such as cell differentiation, as well as in pathophysiological processes such as cancer. There are numerous examples of deregulated lncRNAs in various types of tumors, thereby contributing to different hallmarks of cancer, such as angiogenesis. To exceed a tumor size with a diameter of more than 2 mm, the formation of blood vessels is vital to supply the tumor with sufficient nutrients and oxygen. Recently, studies have reported that lncRNAs regulate tumor angiogenesis by directly or indirectly influencing numerous pathways by binding proteins, interacting with other RNA transcripts or modulating the tumor microenvironment. View this paper
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