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Review

Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu

1
Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany
2
German Center for Lung Research (DZL), 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Received: 30 September 2020 / Revised: 26 October 2020 / Accepted: 5 November 2020 / Published: 9 November 2020
(This article belongs to the Collection Feature Papers in Non-coding RNA)
While the important functions of long noncoding RNAs (lncRNAs) in nuclear organization are well documented, their orchestrating and architectural roles in the cytoplasmic environment have long been underestimated. However, recently developed fractionation and proximity labelling approaches have shown that a considerable proportion of cellular lncRNAs is exported into the cytoplasm and associates nonrandomly with proteins in the cytosol and organelles. The functions of these lncRNAs range from the control of translation and mitochondrial metabolism to the anchoring of cellular components on the cytoskeleton and regulation of protein degradation at the proteasome. In the present review, we provide an overview of the functions of lncRNAs in cytoplasmic structures and machineries und discuss their emerging roles in the coordination of the dense intracellular milieu. It is becoming apparent that further research into the functions of these lncRNAs will lead to an improved understanding of the spatiotemporal organization of cytoplasmic processes during homeostasis and disease. View Full-Text
Keywords: Long noncoding RNA; lncRNA; cytoplasm; cytosol; translation; organelles; phase-separation Long noncoding RNA; lncRNA; cytoplasm; cytosol; translation; organelles; phase-separation
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MDPI and ACS Style

Aillaud, M.; Schulte, L.N. Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu. Non-Coding RNA 2020, 6, 44. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna6040044

AMA Style

Aillaud M, Schulte LN. Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu. Non-Coding RNA. 2020; 6(4):44. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna6040044

Chicago/Turabian Style

Aillaud, Michelle, and Leon N. Schulte 2020. "Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu" Non-Coding RNA 6, no. 4: 44. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna6040044

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