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Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers

1
Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
2
Department of Human Anatomy and Embryology, University of Extremadura, 06006 Badajoz, Spain
3
Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain
4
Fundación Medina, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Received: 21 January 2021 / Revised: 14 February 2021 / Accepted: 15 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Non-coding RNA: 5th Anniversary)
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. View Full-Text
Keywords: retinoic acid; microRNAs; lncRNAs; development; disease retinoic acid; microRNAs; lncRNAs; development; disease
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MDPI and ACS Style

García-Padilla, C.; Lozano-Velasco, E.; López-Sánchez, C.; Garcia-Martínez, V.; Aranega, A.; Franco, D. Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers. Non-Coding RNA 2021, 7, 13. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010013

AMA Style

García-Padilla C, Lozano-Velasco E, López-Sánchez C, Garcia-Martínez V, Aranega A, Franco D. Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers. Non-Coding RNA. 2021; 7(1):13. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010013

Chicago/Turabian Style

García-Padilla, Carlos, Estefanía Lozano-Velasco, Carmen López-Sánchez, Virginio Garcia-Martínez, Amelia Aranega, and Diego Franco. 2021. "Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers" Non-Coding RNA 7, no. 1: 13. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010013

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