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Article

MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2

1
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität (LMU), 800336 Munich, Germany
2
IRCCS Casa sollievo della Sofferenza, Laboratory of Bioinformatics, 71013 San Giovanni Rotondo (FG), Italy
3
German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80336 Munich, Germany
4
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands
5
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany
6
Council for Agricultural Research and Economics, Research Center for Food and Nutrition, 00178 Rome, Italy
7
Biotechnology and Biopharmaceutics, Department of Biosciences, University of Bari Aldo Moro, 70125 Bari, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Received: 12 January 2021 / Revised: 9 February 2021 / Accepted: 16 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue RNA Therapeutics: From Concepts to Applications)
The respiratory system is one of the most affected targets of SARS-CoV-2. Various therapies have been utilized to counter viral-induced inflammatory complications, with diverse success rates. Pending the distribution of an effective vaccine to the whole population and the achievement of “herd immunity”, the discovery of novel specific therapies is to be considered a very important objective. Here, we report a computational study demonstrating the existence of target motifs in the SARS-CoV-2 genome suitable for specific binding with endogenous human micro and long non-coding RNAs (miRNAs and lncRNAs, respectively), which can, therefore, be considered a conceptual background for the development of miRNA-based drugs against COVID-19. The SARS-CoV-2 genome contains three motifs in the 5′UTR leader sequence recognized by selective nucleotides within the seed sequence of specific human miRNAs. The seed of 57 microRNAs contained a “GGG” motif that promoted leader sequence-recognition, primarily through offset-6mer sites able to promote microRNAs noncanonical binding to viral RNA. Similarly, lncRNA H19 binds to the 5′UTR of the viral genome and, more specifically, to the transcript of the viral gene Spike, which has a pivotal role in viral infection. Notably, some of the non-coding RNAs identified in our study as candidates for inhibiting SARS-CoV-2 gene expression have already been proposed against diverse viral infections, pulmonary arterial hypertension, and related diseases. View Full-Text
Keywords: oligosequences; SARS-CoV-2; COVID-19; target therapy; non-coding RNAs oligosequences; SARS-CoV-2; COVID-19; target therapy; non-coding RNAs
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MDPI and ACS Style

Natarelli, L.; Parca, L.; Mazza, T.; Weber, C.; Virgili, F.; Fratantonio, D. MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Non-Coding RNA 2021, 7, 14. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010014

AMA Style

Natarelli L, Parca L, Mazza T, Weber C, Virgili F, Fratantonio D. MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Non-Coding RNA. 2021; 7(1):14. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010014

Chicago/Turabian Style

Natarelli, Lucia, Luca Parca, Tommaso Mazza, Christian Weber, Fabio Virgili, and Deborah Fratantonio. 2021. "MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2" Non-Coding RNA 7, no. 1: 14. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010014

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