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The Role of LncRNAs in Translation
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The Implications of ncRNAs in the Development of Human Diseases

1
Centre for Haematology, Immunology and Inflammation Department, Faculty of Medicine, Imperial College London, London W12 0NN, UK
2
Unidad de Bioinformática, Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Científicas, 18016 Granada, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael Janitz
Received: 23 December 2020 / Revised: 14 February 2021 / Accepted: 19 February 2021 / Published: 24 February 2021
The mammalian genome comprehends a small minority of genes that encode for proteins (barely 2% of the total genome in humans) and an immense majority of genes that are transcribed into RNA but not encoded for proteins (ncRNAs). These non-coding genes are intimately related to the expression regulation of protein-coding genes. The ncRNAs subtypes differ in their size, so there are long non-coding genes (lncRNAs) and other smaller ones, like microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs). Due to their important role in the maintenance of cellular functioning, any deregulation of the expression profiles of these ncRNAs can dissemble in the development of different types of diseases. Among them, we can highlight some of high incidence in the population, such as cancer, neurodegenerative, or cardiovascular disorders. In addition, thanks to the enormous advances in the field of medical genomics, these same ncRNAs are starting to be used as possible drugs, approved by the FDA, as an effective treatment for diseases. View Full-Text
Keywords: ncRNAs; lncRNAs; circRNAs; piRNAs; miRNAs in cancer; cardiovascular and neurodegenerative diseases ncRNAs; lncRNAs; circRNAs; piRNAs; miRNAs in cancer; cardiovascular and neurodegenerative diseases
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MDPI and ACS Style

López-Jiménez, E.; Andrés-León, E. The Implications of ncRNAs in the Development of Human Diseases. Non-Coding RNA 2021, 7, 17. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010017

AMA Style

López-Jiménez E, Andrés-León E. The Implications of ncRNAs in the Development of Human Diseases. Non-Coding RNA. 2021; 7(1):17. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010017

Chicago/Turabian Style

López-Jiménez, Elena, and Eduardo Andrés-León. 2021. "The Implications of ncRNAs in the Development of Human Diseases" Non-Coding RNA 7, no. 1: 17. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010017

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