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Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer

1
School of Biological Sciences (SBS), Nanyang Technological University (NTU), 60 Nanyang Drive, Singapore 637551, Singapore
2
Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore 138673, Singapore
*
Authors to whom correspondence should be addressed.
Received: 29 January 2021 / Revised: 28 February 2021 / Accepted: 5 March 2021 / Published: 9 March 2021
It is becoming increasingly evident that the non-coding genome and transcriptome exert great influence over their coding counterparts through complex molecular interactions. Among non-coding RNAs (ncRNA), long non-coding RNAs (lncRNAs) in particular present increased potential to participate in dysregulation of post-transcriptional processes through both RNA and protein interactions. Since such processes can play key roles in contributing to cancer progression, it is desirable to continue expanding the search for lncRNAs impacting cancer through post-transcriptional mechanisms. The sheer diversity of mechanisms requires diverse resources and methods that have been developed and refined over the past decade. We provide an overview of computational resources as well as proven low-to-high throughput techniques to enable identification and characterisation of lncRNAs in their complex interactive contexts. As more cancer research strategies evolve to explore the non-coding genome and transcriptome, we anticipate this will provide a valuable primer and perspective of how these technologies have matured and will continue to evolve to assist researchers in elucidating post-transcriptional roles of lncRNAs in cancer. View Full-Text
Keywords: lncRNA; cancer; post-transcription; RNA-binding; ribonucleoprotein; RNAi; interactome; prediction; database; CLIP lncRNA; cancer; post-transcription; RNA-binding; ribonucleoprotein; RNAi; interactome; prediction; database; CLIP
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MDPI and ACS Style

Carter, J.-M.; Ang, D.A.; Sim, N.; Budiman, A.; Li, Y. Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer. Non-Coding RNA 2021, 7, 19. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010019

AMA Style

Carter J-M, Ang DA, Sim N, Budiman A, Li Y. Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer. Non-Coding RNA. 2021; 7(1):19. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010019

Chicago/Turabian Style

Carter, Jean-Michel, Daniel A. Ang, Nicholas Sim, Andrea Budiman, and Yinghui Li. 2021. "Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer" Non-Coding RNA 7, no. 1: 19. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010019

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