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LncRNAs in Cardiomyocyte Maturation: New Window for Cardiac Regenerative Medicine

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 111-14115, Iran
*
Author to whom correspondence should be addressed.
Received: 6 February 2021 / Revised: 5 March 2021 / Accepted: 8 March 2021 / Published: 10 March 2021
Cardiomyocyte (CM) maturation, which is characterized by structural, functional, and metabolic specializations, is the last phase of CM development that prepares the cells for efficient and forceful contraction throughout life. Over the past decades, CM maturation has gained increased attention due to the fact that pluripotent stem cell-derived CMs are structurally, transcriptionally, and functionally immature and embryonic-like, which causes a defect in cell replacement therapy. The current challenge is to discover and understand the molecular mechanisms, which control the CM maturation process. Currently, emerging shreds of evidence emphasize the role of long noncoding RNAs (lncRNAs) in regulating different aspects of CM maturation, including myofibril maturation, electrophysiology, and Ca2+ handling maturation, metabolic maturation and proliferation to hypertrophy transition. Here, we describe the structural and functional characteristics of mature CMs. Furthermore, this review highlights the lncRNAs as crucial regulators of different aspects in CM maturation, which have the potential to be used for mature CM production. With the current advances in oligonucleotide delivery; lncRNAs may serve as putative therapeutic targets to produce highly mature CMs for research and regenerative medicine. View Full-Text
Keywords: cardiomyocyte maturation; lncRNAs; myofibril maturation; regenerative medicine cardiomyocyte maturation; lncRNAs; myofibril maturation; regenerative medicine
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MDPI and ACS Style

Kay, M.; Soltani, B.M. LncRNAs in Cardiomyocyte Maturation: New Window for Cardiac Regenerative Medicine. Non-Coding RNA 2021, 7, 20. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010020

AMA Style

Kay M, Soltani BM. LncRNAs in Cardiomyocyte Maturation: New Window for Cardiac Regenerative Medicine. Non-Coding RNA. 2021; 7(1):20. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010020

Chicago/Turabian Style

Kay, Maryam, and Bahram M. Soltani 2021. "LncRNAs in Cardiomyocyte Maturation: New Window for Cardiac Regenerative Medicine" Non-Coding RNA 7, no. 1: 20. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010020

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