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Review

Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message

1
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
2
Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Frenchay, Bristol BS16 1QY, UK
*
Authors to whom correspondence should be addressed.
Received: 21 January 2021 / Revised: 5 February 2021 / Accepted: 22 February 2021 / Published: 11 March 2021
Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type- and tissue-specific manner, and defects in alternative splicing can dramatically alter RNA and protein functions and lead to disease. The eukaryotic genome is also intensively transcribed into long and short non-coding RNAs which account for up to 90% of the entire transcriptome. Over the years, lncRNAs have received considerable attention as important players in the regulation of cellular processes including alternative splicing. In this review, we focus on recent discoveries that show how lncRNAs contribute significantly to the regulation of alternative splicing and explore how they are able to shape the expression of a diverse set of splice isoforms through several mechanisms. With the increasing number of lncRNAs being discovered and characterized, the contribution of lncRNAs to the regulation of alternative splicing is likely to grow significantly. View Full-Text
Keywords: long non-coding RNAs; alternative splicing; splicing factors; post-transcriptional regulation long non-coding RNAs; alternative splicing; splicing factors; post-transcriptional regulation
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MDPI and ACS Style

Pisignano, G.; Ladomery, M. Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message. Non-Coding RNA 2021, 7, 21. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010021

AMA Style

Pisignano G, Ladomery M. Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message. Non-Coding RNA. 2021; 7(1):21. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010021

Chicago/Turabian Style

Pisignano, Giuseppina, and Michael Ladomery. 2021. "Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message" Non-Coding RNA 7, no. 1: 21. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010021

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