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Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective

1
Department of Genetics at the Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto, São Paulo 14049-900, Brazil
2
National Institute of Science and Technology in Stem Cell and Cell Therapy and Center for Cell Based Therapy, Ribeirão Preto Medical School, University of São Paulo, Rua Tenente Catão Roxo, 2501, Monte Alegre, Ribeirão Preto 14051-140, Brazil
3
Center for Integrative Systems Biology-CISBi, NAP/USP, Ribeirão Preto Medical School, University of São Paulo, Rua Catão Roxo, 2501, Monte Alegre, Ribeirão Preto 14051-140, Brazil
4
Department of Medicine at the Midwest State University of Paraná-UNICENTRO, and Guarapuava Institute for Cancer Research, Rua Fortim Atalaia, 1900, Cidade dos Lagos, Guarapuava 85100-000, Brazil
*
Author to whom correspondence should be addressed.
Received: 12 November 2020 / Revised: 5 December 2020 / Accepted: 7 December 2020 / Published: 11 March 2021
(This article belongs to the Special Issue Role of lncRNAs in Brain Development and Disease)
Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it difficult to understand its etiology. Long noncoding RNAs (lncRNAs) comprise a large group of transcripts that can act through various mechanisms and be involved in important neurodevelopmental processes. In this sense, comprehending the roles they play in this intricate context is a valuable way of getting new insights about how NS-ID can arise and develop. In this review, we attempt to bring together knowledge available in the literature about lncRNAs involved with molecular and cellular pathways already described in intellectual disability and neural function, to better understand their relevance in NS-ID and the regulatory complexity of this disorder. View Full-Text
Keywords: long noncoding RNA; non-syndromic intellectual disability; molecular and cellular pathways; neurodevelopment; neural function long noncoding RNA; non-syndromic intellectual disability; molecular and cellular pathways; neurodevelopment; neural function
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MDPI and ACS Style

Barros, I.I.; Leão, V.; Santis, J.O.; Rosa, R.C.A.; Brotto, D.B.; Storti, C.B.; Siena, Á.D.D.; Molfetta, G.A.; Silva, W.A., Jr. Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective. Non-Coding RNA 2021, 7, 22. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010022

AMA Style

Barros II, Leão V, Santis JO, Rosa RCA, Brotto DB, Storti CB, Siena ÁDD, Molfetta GA, Silva WA Jr.. Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective. Non-Coding RNA. 2021; 7(1):22. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010022

Chicago/Turabian Style

Barros, Isabela I., Vitor Leão, Jessica O. Santis, Reginaldo C.A. Rosa, Danielle B. Brotto, Camila B. Storti, Ádamo D.D. Siena, Greice A. Molfetta, and Wilson A. Silva Jr. 2021. "Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective" Non-Coding RNA 7, no. 1: 22. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010022

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