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Exosomes in Immune Regulation

1
Department of Gynecology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
2
Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
3
Fondazione “Enrico Puccinelli” Onlus, 06126 Perugia, Italy
*
Author to whom correspondence should be addressed.
Received: 9 November 2020 / Revised: 26 December 2020 / Accepted: 4 January 2021 / Published: 8 January 2021
(This article belongs to the Collection Feature Papers in Non-coding RNA)
Exosomes, small extracellular vesicles mediate intercellular communication by transferring their cargo including DNA, RNA, proteins and lipids from cell to cell. Notably, in the immune system, they have protective functions. However in cancer, exosomes acquire new, immunosuppressive properties that cause the dysregulation of immune cells and immune escape of tumor cells supporting cancer progression and metastasis. Therefore, current investigations focus on the regulation of exosome levels for immunotherapeutic interventions. In this review, we discuss the role of exosomes in immunomodulation of lymphoid and myeloid cells, and their use as immune stimulatory agents to elicit specific cytotoxic responses against the tumor. View Full-Text
Keywords: immune therapy; immune cells; extracellular vesicles; non-coding RNAs; microRNAs immune therapy; immune cells; extracellular vesicles; non-coding RNAs; microRNAs
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MDPI and ACS Style

Schwarzenbach, H.; Gahan, P.B. Exosomes in Immune Regulation. Non-Coding RNA 2021, 7, 4. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010004

AMA Style

Schwarzenbach H, Gahan PB. Exosomes in Immune Regulation. Non-Coding RNA. 2021; 7(1):4. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010004

Chicago/Turabian Style

Schwarzenbach, Heidi, and Peter B. Gahan 2021. "Exosomes in Immune Regulation" Non-Coding RNA 7, no. 1: 4. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010004

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