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Article

miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells

1
Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA
2
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80100 Naples, Italy
3
Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY 10461, USA
4
Department of Advanced Biomedical Science, “Federico II” University, and International Translational Research and Medical Education (ITME), 80131 Naples, Italy
5
AORN “Antonio Cardarelli”, 80100 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: George A. Calin
Received: 30 December 2020 / Revised: 29 January 2021 / Accepted: 31 January 2021 / Published: 2 February 2021
(This article belongs to the Special Issue Non-coding RNA: 5th Anniversary)
Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes including angiogenesis and immunity. Recent evidence has also shown that it is implied in the cellular internalization of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). We hypothesized that specific microRNAs can target Neuropilin-1. By combining bioinformatic and functional approaches, we identified miR-24 as a regulator of Neuropilin-1 transcription. Since Neuropilin-1 has been shown to play a key role in the endothelium-mediated regulation of the blood-brain barrier, we validated miR-24 as a functional modulator of Neuropilin-1 in human brain microvascular endothelial cells (hBMECs), which are the most suitable cell line for an in vitro blood–brain barrier model. View Full-Text
Keywords: ACE2; Akt; blood–brain barrier; brain; coronavirus; CD304; COVID-19; endothelium; epigenetics; hBMEC; microRNA; miR-24-3p; neurology; non-coding RNA; NRP1; SARS-CoV-2; vascular permeability; VEGF; VEGF165R ACE2; Akt; blood–brain barrier; brain; coronavirus; CD304; COVID-19; endothelium; epigenetics; hBMEC; microRNA; miR-24-3p; neurology; non-coding RNA; NRP1; SARS-CoV-2; vascular permeability; VEGF; VEGF165R
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MDPI and ACS Style

Mone, P.; Gambardella, J.; Wang, X.; Jankauskas, S.S.; Matarese, A.; Santulli, G. miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells. Non-Coding RNA 2021, 7, 9. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010009

AMA Style

Mone P, Gambardella J, Wang X, Jankauskas SS, Matarese A, Santulli G. miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells. Non-Coding RNA. 2021; 7(1):9. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010009

Chicago/Turabian Style

Mone, Pasquale, Jessica Gambardella, Xujun Wang, Stanislovas S. Jankauskas, Alessandro Matarese, and Gaetano Santulli. 2021. "miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells" Non-Coding RNA 7, no. 1: 9. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010009

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