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LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA
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Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 5 August 2021 / Revised: 25 August 2021 / Accepted: 26 August 2021 / Published: 28 August 2021
(This article belongs to the Special Issue RNA Therapeutics: From Concepts to Applications)
Long non-coding RNA (lncRNA) TP53 target 1 (TP53TG1) was discovered as a TP53 target gene. TP53TG1 has been reported as having dual roles by exerting tumor-suppressive and oncogenic activities that vary depending on the cancer type. Yet, the role of TP53TG1 in hepatocellular carcinoma (HCC) is not fully understood. In this study, we performed both gain- and loss-of-function studies to determine the biological role of TP53TG1 in HCC. We found that the knockdown of TP53 in HCC cells caused the upregulation of TP53TG1. Furthermore, we found that the knockdown of TP53TG1 not only suppressed HCC cell proliferation and migration, but also reduced intrinsic ERK signaling. In contrast, the overexpression of TP53TG1 increased ERK activation and enhanced HCC proliferation. In conclusion, our study reveals an oncogenic role of TP53TG1 in HCC, which provides a novel insight into the cell-type-specific function of TP53TG1 in HCC. View Full-Text
Keywords: long non-coding RNA; TP53TG1; hepatocellular carcinoma; ERK pathway; oncogene long non-coding RNA; TP53TG1; hepatocellular carcinoma; ERK pathway; oncogene
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MDPI and ACS Style

Lu, Q.; Guo, Q.; Xin, M.; Lim, C.; Gamero, A.M.; Gerhard, G.S.; Yang, L. LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling. Non-Coding RNA 2021, 7, 52. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7030052

AMA Style

Lu Q, Guo Q, Xin M, Lim C, Gamero AM, Gerhard GS, Yang L. LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling. Non-Coding RNA. 2021; 7(3):52. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7030052

Chicago/Turabian Style

Lu, Qingchun, Qian Guo, Mingyang Xin, Casey Lim, Ana M. Gamero, Glenn S. Gerhard, and Ling Yang. 2021. "LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling" Non-Coding RNA 7, no. 3: 52. https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7030052

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