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Review

Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors

1
Lab of Analytical Chemistry, Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Tokyo 102-8554, Japan
2
Integrated Systems Laboratory, Ecole polytechnique fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
3
Integrated Circuits Laboratory, Ecole polytechnique fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
4
Lab of Analytical Chemistry, Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Tokyo 102-8554, Japan
*
Author to whom correspondence should be addressed.
Submission received: 14 October 2019 / Revised: 14 November 2019 / Accepted: 25 November 2019 / Published: 27 November 2019
(This article belongs to the Special Issue Carbon Nanostructures for Biological Applications)

Abstract

:
Cyclodextrins (CDs) are oligosaccharides composed of six (α), seven (β) or eight (γ) glucose units. Their inner hydrophobic cavity and hydrophilic external surface enable the formation of the “host-guest inclusion complex” with different organic or inorganic molecules showing high molecular selectivity. For these characteristics, CDs have many potential applications in electrochemical sensing. To enable CDs immobilization on the electrode surfaces, different chemical modifications are needed depending of the electrode material, while nanomaterials have been exploited to enhance the sensing signal. The CDs binding onto gold nanoparticles or carbon nanotubes, as an electron-transfer mediator to the electrode surface, is a typical example of it, while also graphene is largely used. The aim of the present review is to give an overview of CDs properties and their applications to electrochemical sensors for medical diagnostics. Different kinds for the functionalization of CDs onto electrode surfaces will be reviewed as well as their performance in presence of nanomaterials. Finally, CDs-based devices for sensing biomedical molecules of biomedical interest will be briefly presented and discussed.

Graphical Abstract

1. Introduction

“Personalized health care” is an urgent need that is taking more and more relevance in medicine. It consists in calibrate and regulate decisions, practices and interventions, depending on the individual patient’ characteristics and includes many fields of medicine, from diagnostic to therapy. Particularly, therapy is one of the major branches of medicine that may benefit of “personalized treatments” since it approaches the right doses at the right moment, avoiding to expose the patient to un-intentional risks. Indeed, drug response is different for every patient because it depends on genetics, epigenetics and phenotyping, while many other factors (e.g., attitude of life, age, environments, environmental exposure, etc.) take a role as well. For these reasons, monitoring human metabolism in real time would be more often required to obtain “the right drug, at the right dose, in the right moment” to finely adjust the drugs therapy on each single patient.
Over the years, electrochemical devices have been proposed for the detection of organic and biomolecules due to their easy and low-cost manufacturing processes as well as for the possibility to realize a multi-panel system for the simultaneous detection of several human metabolites, also “in continua” instead of one-shot measurements [1]. Moreover, they also allow easy assembly with electronic systems for reading and transmitting acquired data.
On the other hand, electrochemistry is in continuous progress: enzyme-based biosensors have been largely developed for sensing metabolites like glucose and lactate, but also for the detection of drugs (e.g., cytochromes-based biosensors proposed for the detection of etoposide, ifosfamide, cyclophosphamide and ftorafur [2], four well known used anti-cancer compounds largely used in chemotherapy).
However, enzymes possess some intrinsic limitations, such as the lowering of their activity in time once attached onto electrode surfaces [3], which may also result in decreasing-in-time the performance of enzyme-based biosensors as, for example, registered in the continuous monitoring of the naproxen [4] a well-known anti-inflammatory compound.
For these reasons, new sensing strategies have been considered and cyclodextrins (CDs) have been selected as potential candidates to provide selectivity to future electrochemical sensing-devices. Cyclodextrins are oligosaccharides composed of six (α), seven (β) or eight (γ) glucose units. Their inner hydrophobic cavity and hydrophilic exterior are enabled to form a “host–guest inclusion complex” targeting different organic or inorganic molecules, toward which usually show high molecular selectivity.
Particularly for electrochemical devices, β-CDs are the most commonly used since their ring-size well matches with a large number of target diagnostic-molecules and since, usually, they are enough low-costs material [5].
Therefore, the aim of the present review is to provide an overview of CDs properties and of the different methods of integration in electrochemical sensors. Various chemical modifications of CDs will be described as well, and the possibility of their co-immobilization with nanomaterials for enhanced sensing will be described too. The final section closes the paper by focusing on CDs-based sensors for biomedical applications.

2. Chemical Modifications of CDs for Electrochemical Devices

The hydroxy groups at the edge of inner cavity of the cyclodextrins establish hydrogen bonds among their OH groups to form their classic bucket structure and provide electrostatic and dipole–dipole interactions with target molecules. In fact, depending on the stereoscopic structure and on the matching-size of the target-molecule, typically the “host-guest inclusion complexes” with CDs is resulting in a specific binding-constant and binding-strength. Considering the hydrophilic nature of the external walls of the cavity, the main forces for the molecular recognition are indeed provided mostly by hydrogen bonds in natural CDs or mostly by electrostatic ones in CDs chemically modified.
Among the several kinds of cyclodextrins, β-CDs are the most commonly used in electrochemistry since their cavities allow the best-performing inclusion. However, they are the less soluble in water than α-CDs and γ-CDs, since their intermolecular hydrogen bonds prevent the formation of hydrogen bonds with the surrounding water molecules [5].
The solubility in water of CDs increases by introducing chemical functional groups in the surface of the molecule. This usually also results in better capacity of immobilization onto substrates for sensing aims.
Starting from natural CDs, it is possible to synthetize different kinds of CDs derivatives [5].
The first type of CDs derivatives belong to the class of carboxymethyl-CDs (CM-CDs) [6]. In this class, the carboxymethyl group located at the edge of the cavity changes the characteristic hydrogen bond configuration of CDs since hydrogen bonds are established among the hydrogen atoms of the carboxyl groups and the hydrogen atoms of the water molecules, which improve the CDs solubility in water [5,7].
Instead of in hydroxyl groups, the second type of CDs derivatives is obtained by the introduction of amino-groups, typically with an ethylenediamine on the 6th position of the CD. The amino-groups at the edge of the cavity establish hydrogen bonds and dipolar interactions with other water molecules. On the other hand, under acidic conditions, amino groups go to protonation that results in electrostatic interactions and hydrogen bonds with other interacting molecules [5].
Since they can form a covalent bonding with gold electrode or gold nanoparticles [8,9] (GNPs), a third category of CDs of interest in electrochemistry is that of thiolated-CDs (SH-β-CDs) [10,11] (both mono or multi-thiolated). Weisser et al. [12] investigated four different kinds of mono or multi SH-β-CDs with different chain-length, with respect to their absorption and orientation onto gold electrodes. They concluded that the mono-thiolated CDs with a long carbon chain can form densely packed monolayers but also physisorbed undesired adlayers. Another approach is to obtain SH-CDs by reduction with mercaptoethanol after the substitution of tosylated-CDs (TS-CDs). In this way, multi-thiolated CDs with amino-group inserted in the chain have been obtained [13,14,15].
Another possible CDs derivative class is that of hydroxypropyl-CDs (HP-CDs), instead largely used on carbon substrates. The most common method to synthetize HP-CDs is through a reaction of condensation of β-CDs with propylene oxide, at low temperature and under catalysis in basic solution (NaOH) [5,16].
Other CDs derivatives for more specific electrochemical applications are represented by succinyl-CDs [17], per-6-deoxy-per-6-(2-carboxy-methyl)thio-β-cyclodextrin (AcSCD) [18], lipoyl-CDs [19] or disulfides bridged two adjacent β-CDs (DB-β-CDs) [20].
Possible chemical modifications of CDs and their interactions with different electrode materials are shown in Table 1.

3. Immobilization Strategies on Electrode Surfaces

As mentioned before, nanomaterials are often used to functionalize metallic surfaces for sensing aims. In literature, there are many methods for binding CDs to nanomaterials such as gold nanoparticles (GNPs) [21], or carbon nanomaterials such as carbon nanotubes (CNTs) [22], graphene [23] or fullerenes [24]. On the other hand, literature also shows many examples of inclusion of CDs in conductive polymers [25] to functionalization aims. Bottom up techniques have also been proposed [26] as a possibility to deposit CDs directly onto the electrode surface. In the following three paragraphs different kinds of CDs immobilization onto gold and carbon electrodes are described (Scheme 1).

3.1. Inclusion of CDs onto Gold Electrode

3.1.1. Covalent Bond with SH-β-CDs

Like previously reported, different SH-β-CDs for electrochemical analysis have been considered in the last 30 years. They can be split in two main categories: “pure” SH-β-CDs (mono or multi-thiolated), and “not pure” SH-β-CDs, with the insertion of amino groups in the chain.
Dealing with the “pure” SH-β-CDs, Rojas et al. [10] synthetized multi-thiolated CDs derivatives that have been largely used in the following years to obtain CDs covalently bonded to gold electrodes or to GNPs. For example, Di Palma et al. [27] proposed a simple and reversible protein assemblies on well-oriented β-CD moieties tethered onto a gold surface.
In order to guarantee more mobility to the CDs once at the surface, and to facilitate the inclusion with target molecules [28], mono-thiolated CDs have been developed too. Fu et al. [9] synthetized mono-6-thio-β-CDs using the method of Wang et al. [11]. After the electrodeposition of gold nanoparticles (GNPs) onto carbon electrode previously functionalized with single-walled carbon nanotubes (SWCNTs), the electrode has been immersed in SH-β-CDs methanol solution to obtain an Au-SH linkage. The pesticide methyl parathion has been then sensed by exploiting the host-guest inclusion property of the SH-β-CDs.

3.1.2. Electrostatic Bonding

Even if the covalent binding of the thiolated group ensures the right orientation of CDs on the electrode surface, defect densities due to the lack of favorable lateral interaction between the CD molecules could occur [10]. Moreover, the incorporation of multiple and symmetrically distributed thiol groups on the CD could result in poor packing of the monolayer [26]. For these reasons, other approaches to obtain a well-oriented self-assembled-monolayer (SAM) of CDs onto the gold surface have been exploited.
One of these could be the interaction of CDs with gold electrode through opposite charges. Godinez et al. [29] demonstrated that the aggregation to the CDs of amphiphilic chains with positively charged amino groups not only permits a certain degree of packing and thickness of the multilayer assembly but also the specific orientation of the adsorbed amphiphiles.

3.1.3. Self-Assembly

The functionalization of CDs with long alkyl thiothers as spacers allows obtaining self-assembled structures with improved surface coverage and order [30]. However, the incorporation of alkyl chains decreases the conductivity of the organic molecules that hampers their use in applications based on electron transfer processes [31]. Therefore, alternatives to immobilize CDs with a proper orientation on gold electrodes without the synthesis of thiol-modified cyclodextrins is also proposed by bottom up techniques. These techniques typically consist on chemical modifications of gold surfaces in order to then subsequently bind CDs on top.
M. Garcìa et al. [26] evaluated the possibility of immobilization of amino-β-CDs on gold surfaces via three different bottom up approaches: (i) direct adsorption, (ii) amide-bond formation with the carboxylic groups of a self-assembled monolayer of 4-mercapto benzoic acid (4-MBA) and (iii) covalent bond among carboxylic and amine groups of electrografted diazonium salt previously synthesized in situ by 4-amino benzoic acid (4-ABA; Scheme 2).
The work of M. Garcìa et al. demonstrated that, in the case of the well-ordered and packed thiolated layer, the surface coverage was proportional to the number of amine groups, while the porous structure of the electrografted diazonium layer allowed a higher level of surface coverage of disordered molecules. Then, Mèndez-Torres et al. [32] demonstrated the covalent immobilization of CDs to gold electrode by using the Garcia’s bottom up strategy, but they obtained the CD cavity opposite oriented with respect to the gold surface. In such a configuration, the host-guest interactions can be enhanced since the CDs cavity is well exposed out of the surface. Their results show the feasibility to use such modified surfaces for molecular recognition as an alternative way to other more usually proposed conventional molecules, such as antigens, antibodies, enzymes, etc.
Yang et al. [33] proposed a different functionalization of three gold working electrodes (WEs) forming a multi-panel system for the detection of the three major catecholamine hormones: L-tyrosine, dihydroxyphenylalanine (L-DOPA) and dopamine. First, each one of the WEs was chemically treated to obtain a hydrophilic character. Then, each of the three WEs was finally functionalized with a different kind of CDs: different α-, β- or γ-CDs have been used in order to obtain sensors to selectively detect different hormones by exploiting the different size of the cavity (Scheme 3).
It worth to note that, in this kind of bottom up approach, it is not required to use amino-CDs, while CDs of any other class of derivatives are possible to be used to functionalize the gold electrodes.

3.2. Deposition Method for Both Gold and Carbon Electrode: Electropolymerization

As an alternative to chemically modified CDs immobilization, electropolymerization of CDs has been successfully proposed too for the deposition of CDs onto sensing surfaces. There are different techniques of electropolymerization, mainly divided in two categories: (i) direct electropolymerization of CDs (direct electrodeposition of CDs), and (ii) inclusion (or entrapment) of CDs into electrodeposited polymeric films.

3.2.1. Direct Electropolymerization of CDs

This kind of polymerization could be considered as “one step” polymerization since it uses the property of CDs themselves to polymerize, while a “two-steps” electropolymerization is described in the Section 3.2.2.
Li et al. [34] developed an immunosensor by a simple electrochemical polymerization method (Scheme 4). A β-CD polymer (Pβ-CD) was used to modify the glassy carbon electrode (GCE). To enhance the electron transfer property of the modified electrode, and to facilitate the immobilization of the prion Ab, gold nanoparticles (GNPs) were electrochemically deposited on the GCE surface and used as binding-bridge between Pβ-CD film and GCE electrode. Bovine serum albumin (BSA) has been added in order to block the not-specific binding sites, a typical blocking strategy usually proposed to improve the selectivity of the sensing surface [35]. Used as a probe molecule, the ferrocyanide (Fe(CN)6) provides electron transfer, and therefore a Faradaic current, even in the presence of CDs. While the cavity of CDs is blocked to the ferrocyanide in the presence of the prion antibody (PrP) previously interacting to the respective antibody inserted in CDs channel.
Hui et al. [36] used carboxymethyl-β-CDs [6] as a dispersive agent for GNPs that have been electrodeposited onto carbon electrode. A first cyclic voltammetry with a HAuCl4/CM-CDs PBS solution leads to the formation of GNPs onto the electrode surface and a simultaneous functionalization with CM-CDs. Then, a second cyclic voltammetry with only CM-CDs PBS solution allowed the electropolymerization of CDs onto the GNPs surface. The sensor showed electrocatalysis to different drugs and other metabolites (e.g., the glucose) without the use of any specific enzyme (Scheme 5).

3.2.2. Inclusion of CDs into a Polymer Film

A common functionalization method is through two-step electropolymerization: first, a conductive polymer is electrodeposited onto electrode surface, and then CDs are added.
D’Souza et al. [37] developed a dioxygen sensor, by using the polycondensation of β-cyclodextrin soluble prepolymer (β-CDPS) or of carboxymethylated β-cyclodextrin prepolymer (β-CDPA), both hosting electrocatalytically active centers of cobalt tetraphenylporphyrin (TPP). The above-mentioned pre-polymers have been used as coating for the gold electrode surface.
Metal-organic framework (MOF) material with regular and orderly structure has attracted extensive attention for preparing sensors [38,39] as well. More recently, Wu et al. [40] developed a sensor with specific recognition cavities in imprinted microporous-metal-organic-framework (MI-MOF) membrane. Golden nanoparticles (GNPs) have been functionalized by SH-β-CDs and L-cysteine (L-Cys) and then electrodeposited onto electrode together with L-phenylalanine (L-Phe). Afterward, L-Phe has been removed from the CDs cavities by washing in methanol and acetic acid. Finally, cyclic voltammetry and differential pulse voltammetry measurements with different L-Phe target concentrations have demonstrated good selectivity respect to typical interfering molecules of the D-Phenylalanine (D-Phe; Scheme 6).
In this case, the selectivity is obtained by double recognition of CDs and L-cysteine. In fact, the hydrophobic benzene of L-phenylalanine (L-Phe) can be embedded in the CDs cavity, while the other end of the target molecule was captured by the L-cysteine through complementary electrical interactions by dipolar ions. However, D-phenylalanine (D-Phe) cannot be effectively recognized by imprinted cavities contributing to mismatch spatial configuration [40].
Arjomandi et al. [41,42] drugged N-methylpyrrole (NMPy) films with 2,6-dimethyl-β-cyclodextrin for electropolymerization onto gold electrode. G. Bidan et al. [43] did similar analysis for sulphonated cyclodextrins. Finally, Dermody et al. [44] deposited hyperbranched poly(acrylic acid) (PAA) films on Au electrodes. PAA film is a highly functionalized framework to covalently bind natural β-CDs, without any kind of their specific chemical modification.
CDs inclusion into a polymer film is also possible for the functionalization of carbon-based electrodes. For example, polyaniline (PANI) polymer is proposed for directly electrodeposition onto electrode surface [45] or onto a layer of CNTs [46], also in combination with L-glutanic acid (L-Glu) and CDs [47]. Co-electrodeposition of CDs and mono-dispersed nanocarbon onto glass carbon electrode (GCE) by β-CD/reduced-Graphene-Oxide (β-CD/rGO) has been proposed too by Jiang et al. [48].
Of course, a co-electropolymerization of CDs and another monomer-based solution is possible also avoiding the integration of carbon nanomaterials (CNTs or graphene). For example, Zhang et al. [49] developed a sensor for the detection of fluoroquinolones based on hydrogen interactions among L-arginine amino acid (L-arg) with CDs, while Bouchta et al. [50] achieved an electrosynthesis of 3-methylthiphene (P3MT) with β-CDs, through both the potentiostatic and galvanostatic method. Sun’s group [51] polymerized mesoporous carbon onto GCE and, then, β-CDs were included into a poly-dopamine film for the detection of chloramphenicol (CAP).

3.3. Inclusion of CDs onto Carbon Electrode

In recent years, CDs-functionalized carbon materials (carbon nanotubes (CNTs), graphene and fullerene) [52] have been also developed and used in electrochemical sensors. In these cases, it is also possible to observe different functionalization techniques, like the simple mixing of carbon and CDs suspensions with successive drop-casting onto electrode surfaces [53,54]. Electropolymerization methods or chemical modifications of CDs on electrode surfaces have been employed too.

3.3.1. Load of Metal Nanoparticles on Carbon-Based/β-CDs Composites

The host–guest inclusion typical property of CDs could be combined with the increase of active sites and surface area through the loading of metal nanoparticles on carbon-based/β-CDs composite. [5,55,56]. For example, the surface modification of graphene with β-CDs through GNPs insertion could be a promising strategy for electrochemical enhanced sensing [57]. Taking advantage by thiol-binding due to the SH-β-CDs, carbon microspheres are functionalized with CDs due to the introduction of GNPs into carbon microsphere surface [58].

3.3.2. Anchoring Methods Using Chemically Modified CDs

In order to form covalent bonds directly with carbon substrates, CD chemical modifications are necessary.
For example, the carboxymethyl-CDs (CM-CDs)-based composites formed by covalent bonds exhibit high stability, compared to simple mixing, since CM-CDs present carboxyl groups necessary for amidation reaction. Chen et al. [59] used CM-CDs for functionalizing magnetic nanoparticles to design a sandwich immunoassay for the detection of ractopamine (RAC). On the other hand, if the carbon substrate is chemically modified with the COOH group, then amino-CDs can covalently bind. For instance, single-walled carbon nanotubes (SWCNTs) functionalized with 3,4,9,10-perylene tetracarboxylic acid (PTCA) and then stirred with NH2-β-CD based solution can bind CDs [60]. In a similar way, graphene could be also functionalized with NH2-CDs [23].
The HP-CDs derivatives have instead been used to improve the conductivity of carbon electrode for the detection of glutathione (GSH) by using 10-methylphenothiozine (MPT). In fact, the MPT molecules can enter into CDs cavities. In this way, MPT could more rapidly exchange electrons with the electrode and perform the catalytic oxygen reduction of GSH [16]. In many other cases, HP-CDs are immobilized onto graphene [61] or graphene nanoribbons [62] and then the complex is cast on the carbon electrode surface.
We mentioned already the SH group as being fundamental for the CDs covalent binding with gold substrates, but there is one case where it would be possible to use this kind of CD derivatives to directly attach on the carbon substrate. This was done by Yang et al. [63] through the synthesis of a kind of bridged-bis-(β-CDs), starting from a pair of SH-β-CDs. It seems that two adjacent CDs units exhibit more significantly binding abilities and molecular recognition than native or mono-modified CDs. The disulfides bridged β-CD have been bonded to MWCNTs and then dropped onto the sensor for the detection of three different kinds of phenol.
Finally, another interesting and not so-commonly-used CDs chemical modification is the introduction of the pyrene group. In fact, a strong hydrophobic-hydrophobic interaction is guaranteed among CDs and carbon material due to this chemical group, even if this is not a covalent bond. Moreover, CDs result was well exposed and right orientated to the exterior due to the presence of a certain chain. In literature, they have been bonded to CNTs [64,65] (Scheme 7) but they looked at the only kind of CDs that could be bonded directly to glass carbon electrode (GCE) through an immersion of the electrodes in pyrene-CDs solution, without the need of any sonication, centrifugation or filtration.

4. CDs for Biomedical Devices

Many of the electrodes functionalizations with CDs examined in this review article have been fabricated for the detection of molecules related to biomedical detection.
In the most of the cases, the target molecule possesses hydrophobic parts that allow the match with CDs hydrophobic cavities and to facilitate their absorption onto electrode surface. In this case, direct detection is achieved due to the fact that the target molecule is electroactive, so CDs are used as a selective bridge in order to help the hydrophobic target to reach the electrode surface and to directly exchange electrons with the electrodes [33,40,66].
Other types of bio-probes can be: not electroactive, which binds with the target molecule, while the redox reactions take place by other molecules [34,67,68]; while electroactive probes like hydroquinone [45] or ferrocene [69,70] are used in order to detect all those biomolecules that do not possess any electroactive sites. This last kind of detection is indirect detection typically based on competition of electroactive probes and target molecules on CDs. The electroactive probe could enter in the CD cavity instead of the target, increasing its exchanging of electrons with the electrode, which results in a decrease of current (Scheme 8).
The reduced size of CDs permits the detection of many biomolecules whose sizes are inferior of 12–15 nm, like drugs, amino acids, etc. while many other targets may have larger sizes. In this case, CDs are used simply as a dispersing agent of nanoparticles (e.g., of golden nanoparticles (GNPs)) that may better dissolve, reduce their diameter and make the effective surface area increase for enzyme-less detection of glucose [36]. Moreover, Hishiya et al. [72] used CDs immobilized into a conductive polymer as a template to bind hydrophobic parts of cholesterol as shown in Scheme 9.

5. Conclusions

We described in this paper the deposition of CDs for electrochemical sensing. We considered here many CDs chemical modifications, starting from their typical “host–guest complex” shape created by their toroidal structure and then considering different options to further functionalized the molecules for deposition aims. Chemical modifications typically are required to improve their binding properties, their solubility and especially to achieve a better incorporation onto the sensing electrodes.
We focused our attention particularly on different techniques of CDs inclusion onto gold and carbon electrodes. Some techniques consider chemical modifications of CDs (thiolation or pyrene-CDs), others chemical modification of the electrodes (bottom up); or CDs direct electropolymerization (direct electropolymerization) or inclusion of CDs into other conductive polymers then further deposited by electropolymerization.
CDs use in the detection of metabolites and other biomolecules is becoming more relevant in literature for the detection of small organic molecules. The recognition of molecules such as glucose or cholesterol has been already demonstrated. In this respect, CDs have a huge potential as recognition elements once incorporated on electrodes, in order to provide the right selectivity to the final sensing device. The chemical modifications of CDs surfaces open the possibility to explore a variety of sensing mechanisms for several new applications to diagnostics, life science and biology.

Author Contributions

Original draft preparation and writing, M.A.C.; methodology, I.T.; supervision, S.C. and T.H.

Funding

This research received no external funding.

Acknowledgments

Generous financial support from Sophia Alumni Entrepreneurs Club Scholarship, Sophia University are gratefully acknowledged.

Conflicts of Interest

The authors declare no conflict of interest.

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Scheme 1. Different methods of cyclodextrins (CDs) integration onto gold or carbon electrodes.
Scheme 1. Different methods of cyclodextrins (CDs) integration onto gold or carbon electrodes.
Carbon 05 00078 sch001
Scheme 2. Scheme about surface modification methods: (A) Direct adsorption of amino-β-CD onto gold surfaces; (B) covalent attachment by amide bond formation with carboxylic groups of a self assembled monolayer by 4-mercapto-benzoic acid. EDC is for N-(3-dimethylaminopropyl)-N0-ethylcarbodimide and NHS is for N-hydroxysulfosuccinimide; C) covalent bond between amine and carboxyl groups of the electrografted diazonium salt from 4-amino benzoic acid. Reproduced from [26], with permission from Elsevier, 2016.
Scheme 2. Scheme about surface modification methods: (A) Direct adsorption of amino-β-CD onto gold surfaces; (B) covalent attachment by amide bond formation with carboxylic groups of a self assembled monolayer by 4-mercapto-benzoic acid. EDC is for N-(3-dimethylaminopropyl)-N0-ethylcarbodimide and NHS is for N-hydroxysulfosuccinimide; C) covalent bond between amine and carboxyl groups of the electrografted diazonium salt from 4-amino benzoic acid. Reproduced from [26], with permission from Elsevier, 2016.
Carbon 05 00078 sch002
Scheme 3. Scheme of the surface functionalization of gold electrode with CDs by the bottom up method. Reproduced from [33], with permission from SpringerOpen, 2014.
Scheme 3. Scheme of the surface functionalization of gold electrode with CDs by the bottom up method. Reproduced from [33], with permission from SpringerOpen, 2014.
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Scheme 4. Illustration about the fabrication procedure of electrochemical prion immunosensors. Glassy Carbon Electrode (GCE), Bovine Serum Albumin (BSA), prion antibody (PrP), antibody (Ab). Reproduced from [34], with permission from Elsevier, 2014.
Scheme 4. Illustration about the fabrication procedure of electrochemical prion immunosensors. Glassy Carbon Electrode (GCE), Bovine Serum Albumin (BSA), prion antibody (PrP), antibody (Ab). Reproduced from [34], with permission from Elsevier, 2014.
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Scheme 5. Scheme of the fabrication of gold-carboxylmethyl-cyclodextrins (Au-CMCD) electrode and gold-carboxylmethyl-cyclodextrin/cyclodextrin-polymer (Au-CMCD/PCMCD) electrode. Reproduced from [36], with permission from Springer, 2016.
Scheme 5. Scheme of the fabrication of gold-carboxylmethyl-cyclodextrins (Au-CMCD) electrode and gold-carboxylmethyl-cyclodextrin/cyclodextrin-polymer (Au-CMCD/PCMCD) electrode. Reproduced from [36], with permission from Springer, 2016.
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Scheme 6. Schematic of the miroporous metal-organic framework (MI-MOF) sensor. (a) Functionalization of Au nanoparticle with thiolated-CDs and L-Cysteine. (b) Electrodeposition of functionalized Au-nanoparticles and L-Phenylalanine on gold electrode. Reproduced from [40], with permission from Springer, 2017.
Scheme 6. Schematic of the miroporous metal-organic framework (MI-MOF) sensor. (a) Functionalization of Au nanoparticle with thiolated-CDs and L-Cysteine. (b) Electrodeposition of functionalized Au-nanoparticles and L-Phenylalanine on gold electrode. Reproduced from [40], with permission from Springer, 2017.
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Scheme 7. Schematic drawing of pyrenecyclodextrin-decorated single-walled carbon nanotube (SWCNT) hybrids and their interaction with target molecules. Reproduced from [64], with permission from John Wiley and Sons, 2008.
Scheme 7. Schematic drawing of pyrenecyclodextrin-decorated single-walled carbon nanotube (SWCNT) hybrids and their interaction with target molecules. Reproduced from [64], with permission from John Wiley and Sons, 2008.
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Scheme 8. Assay protocol of dual-signaling electrochemical sensor based on the competitive host-guest interaction between β-CD and rhodamine B (RhB) (reporting probe)/1-aminopyrene (1-AP) (target). GC is for Glass Carbon (electrode), GO is for Graphene Oxide, CV is for Cyclic Voltammetry, EG/GC is for Graphene/Carbon (electrode), NAANI is for N-acetylaniline, DPV is for Double Pulse Voltammetry. Reproduced from [71], with permission from John Wiley and Sons, 2013.
Scheme 8. Assay protocol of dual-signaling electrochemical sensor based on the competitive host-guest interaction between β-CD and rhodamine B (RhB) (reporting probe)/1-aminopyrene (1-AP) (target). GC is for Glass Carbon (electrode), GO is for Graphene Oxide, CV is for Cyclic Voltammetry, EG/GC is for Graphene/Carbon (electrode), NAANI is for N-acetylaniline, DPV is for Double Pulse Voltammetry. Reproduced from [71], with permission from John Wiley and Sons, 2013.
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Scheme 9. Molecular imprinting of CD to obtain assemblies as tailor-made receptors. Reproduced from [72], with permission from American Chemical Society, 1999.
Scheme 9. Molecular imprinting of CD to obtain assemblies as tailor-made receptors. Reproduced from [72], with permission from American Chemical Society, 1999.
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Table 1. Cyclodextrins (CDs) chemical modifications and their kind of functionalization to respective substrates.
Table 1. Cyclodextrins (CDs) chemical modifications and their kind of functionalization to respective substrates.
CD DerivativeKind of InteractionCDs Integration Substrate
CM-CDselectrostatic interaction amide linkagegold
NH-CDselectrostatic interaction amide linkagegold/carbon
SH-CDsAu-SH linkagegold
HP-CDselectrostatic interactioncarbon

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Casulli, M.A.; Taurino, I.; Carrara, S.; Hayashita, T. Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors. C 2019, 5, 78. https://0-doi-org.brum.beds.ac.uk/10.3390/c5040078

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Casulli MA, Taurino I, Carrara S, Hayashita T. Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors. C. 2019; 5(4):78. https://0-doi-org.brum.beds.ac.uk/10.3390/c5040078

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Casulli, Maria Antonietta, Irene Taurino, Sandro Carrara, and Takashi Hayashita. 2019. "Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors" C 5, no. 4: 78. https://0-doi-org.brum.beds.ac.uk/10.3390/c5040078

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