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Article

Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10

1
Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11651, Egypt
2
Al-Azhar Center for Fermentation Biotechnology and Applied Microbiology, Al-Azhar University, Nasr City, Cairo 11651, Egypt
3
Department of Botany and Microbiology, Faculty of Science, Suez University, Suez 41522, Egypt
*
Author to whom correspondence should be addressed.
Received: 23 December 2020 / Revised: 22 January 2021 / Accepted: 24 January 2021 / Published: 27 January 2021
Effective lactic acid (LA) production from lignocellulosic biomass materials is challenged by several limitations related to pentose sugar utilization, inhibitory compounds, and/or fermentation conditions. In this study, a newly isolated Bacillus coagulans strain Azu-10 was obtained and showed homofermentative LA production from xylose with optimal fermentation conditions at 50 °C and pH 7.0. Growth of strain Azu-10 and LA-fermentation efficiency were evaluated in the presence of various lignocellulose-derived inhibitors (furans, carboxylic acids, and phenols) at different concentrations. Furanic lignocellulosic-derived inhibitors were completely detoxified. The strain has exhibited high biomass, complete xylose consumption, and high LA production in the presence of 1.0–4.0 g/L furfural and 1.0–5.0 g/L of hydroxymethyl furfural, separately. Moreover, strain Azu-10 exhibited high LA production in the presence of 5.0–15.0 g/L acetic acid, 5.0 g/L of formic acid, and up to 7.0 g/L of levulinic acid, separately. Besides, for phenolic compounds, p-coumaric acid was most toxic at 1.0 g/L, while syringaldehyde or p-hydroxybenzaldehyde, and vanillin at 1.0 g/L did not inhibit LA fermentation. The present study provides an interesting potential candidate for the thermophilic LA fermentation from lignocellulose-derived substrates at the industrial biorefinery level. View Full-Text
Keywords: lactic acid; lignocellulose-inhibitors; furans; Bacillus coagulans; xylose; thermophilic fermentation lactic acid; lignocellulose-inhibitors; furans; Bacillus coagulans; xylose; thermophilic fermentation
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MDPI and ACS Style

Abdel-Rahman, M.A.; Hassan, S.E.-D.; Fouda, A.; Radwan, A.A.; Barghoth, M.G.; Desouky, S.G. Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10. Fermentation 2021, 7, 17. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation7010017

AMA Style

Abdel-Rahman MA, Hassan SE-D, Fouda A, Radwan AA, Barghoth MG, Desouky SG. Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10. Fermentation. 2021; 7(1):17. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation7010017

Chicago/Turabian Style

Abdel-Rahman, Mohamed A., Saad E.-D. Hassan, Amr Fouda, Ahmed A. Radwan, Mohammed G. Barghoth, and Salha G. Desouky 2021. "Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10" Fermentation 7, no. 1: 17. https://0-doi-org.brum.beds.ac.uk/10.3390/fermentation7010017

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