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IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens

1
UMR 152 PharmaDev, Faculté de Pharmacie, Institut de Recherche et Développement, Université Paul Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, France
2
IBMM CNRS, Faculté de Pharmacie, Institut des Biomolécules Max Mousseron, 15 Avenue Charles Flahault, BP 14491, CEDEX 5, 34093 Montpellier, France
3
Sys2Diag UMR 9005 CNRS/ALCEDIAGComplex System Modeling and Engineering for Diagnosis, Cap delta/Parc Euromédecine, 1682 rue de la Valsière CS 61003, CEDEX 4, 34184 Montpellier, France
*
Author to whom correspondence should be addressed.
Received: 3 February 2021 / Revised: 11 March 2021 / Accepted: 19 March 2021 / Published: 23 March 2021
Sequential IgE-binding epitopes were identified on the molecular surface of the Pis v 1 (2S albumin), Pis v 2 (11S globulin/legumin) and Pis v 3 (7S globulin/vicilin)—major allergens from pistachio (Pistacia vera) seeds—using the Spot technique. They essentially consist of hydrophilic and electropositively charged residues well exposed on the surface of the allergens. Most of the epitopic regions identified on Pis v 1 and Pis v 3 do not coincide with the putative N-glycosylation sites and thus are not considered as glycotopes. Surface analysis of these epitopic regions indicates a high degree of conformational similarity with the previously identified epitopic regions of the corresponding allergens Ana o 1 (vicilin), Ana o 2 (legumin) and Ana o 3 (2S albumin) from the cashew (Anacardium occidentale) nut. These results offer a molecular basis for the IgE-binding cross-reactivity often observed between pistachio and cashew nut. They support the recommendation for prescribing pistachio avoidance in cashew allergic patients. Other conformational similarities were identified with the corresponding allergens Ses i 1 (2S albumin), Ses i 3 (vicilin) and Ses i 6 (legumin) from sesame (Sesamum indicum), and Jug r 1 (2S albumin), Jug r 2 (vicilin) and Jug r 4 (legumin) from walnut (Juglans regia). Conversely, conformation of most of the epitopic regions of the pistachio allergens often differs from that of epitopes occurring on the molecular surface of the corresponding Ara h 1 (vicilin), Ara h 2 (2S albumin) and Ara h 3 (legumin) allergens from peanut (Arachis hypogaea). View Full-Text
Keywords: pistachio; cashew nut; sesame; walnut; allergens; IgE-binding epitopes; IgE-binding cross-reactivity pistachio; cashew nut; sesame; walnut; allergens; IgE-binding epitopes; IgE-binding cross-reactivity
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MDPI and ACS Style

Barre, A.; Nguyen, C.; Granier, C.; Benoist, H.; Rougé, P. IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens. Allergies 2021, 1, 63-91. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1010006

AMA Style

Barre A, Nguyen C, Granier C, Benoist H, Rougé P. IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens. Allergies. 2021; 1(1):63-91. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1010006

Chicago/Turabian Style

Barre, Annick, Christophe Nguyen, Claude Granier, Hervé Benoist, and Pierre Rougé. 2021. "IgE-Binding Epitopes of Pis v 1, Pis v 2 and Pis v 3, the Pistachio (Pistacia vera) Seed Allergens" Allergies 1, no. 1: 63-91. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1010006

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