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Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder

1
University of Tsukuba School of Medicine, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
2
International Medical Center, University of Tsukuba Affiliated Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Pierre Rougé
Received: 2 March 2021 / Revised: 2 April 2021 / Accepted: 5 April 2021 / Published: 6 April 2021
(This article belongs to the Section Asthma/Respiratory)
The global COVID-19 pandemic has brought respiratory disease to the forefront of public health, but asthma prevalence has been rising globally for decades. Asthma is mediated by errant immune activation and airway remodeling, but the influences of environment, nutrition, and comorbidities (e.g., asthma-chronic obstructive pulmonary disorder-overlap [ACO]) are still poorly understood. Even as a new generation of biologic-based treatments offer better airway control and reductions in mortality, a lack of prophylactic treatments and mechanistic understanding complicates efforts to prevent pathogenesis. This review will explicate and synthesize current knowledge on the effect of ACO and biologics (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) on pathogenesis, treatment, and prognosis. View Full-Text
Keywords: asthma; prevalence; biologic; ACO; IL-5 asthma; prevalence; biologic; ACO; IL-5
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MDPI and ACS Style

Kusumoto, M.; Mathis, B.J. Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder. Allergies 2021, 1, 92-107. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1020007

AMA Style

Kusumoto M, Mathis BJ. Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder. Allergies. 2021; 1(2):92-107. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1020007

Chicago/Turabian Style

Kusumoto, Misa, and Bryan J. Mathis 2021. "Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder" Allergies 1, no. 2: 92-107. https://0-doi-org.brum.beds.ac.uk/10.3390/allergies1020007

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