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Article

Re-Evaluation of the Prevalence of Permanent Congenital Hypothyroidism in Niigata, Japan: A Retrospective Study

1
Department of Homeostatic Regulation and Development, Division of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
2
Department of Pediatrics, Nagaoka Institute for Severely Handicapped Children, Nagaoka 940-2135, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Bradford L. Therrell
Int. J. Neonatal Screen. 2021, 7(2), 27; https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020027
Received: 29 April 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
(This article belongs to the Collection Newborn Screening in Japan)
Although newborn screening (NBS) for congenital hypothyroidism (CH) in Japan started more than 40 years ago, the prevalence of CH remains unclear. Prevalence estimations among NBS-positive CH individuals include those with transient hypothyroidism and transient hyperthyrotropinemia, and re-evaluation with increasing age is necessary to clarify the actual incidence. Thus, we re-evaluated the incidence of permanent CH. Of the 106,114 patients who underwent NBS in the Niigata Prefecture, Japan, between April 2002 and March 2006, 116 were examined further due to high thyroid-stimulating hormone levels (>8 mIU/L) and were included in the study. We retrospectively evaluated their levothyroxine sodium (LT4) replacement therapy status from the first visit to 15 years of age. Of the 116 NBS-positive patients, 105 (91%) were initially examined in our department. Of these, 72 (69%) started LT4 replacement therapy on the first visit. Subsequently, 27 patients continued LT4 replacement until 15 years of age after multiple re-evaluations. The prevalence of permanent CH in the Niigata Prefecture during this period was 1 in 2500–3500 children. Ultimately, 62.5% of patients on LT4 replacement discontinued treatment by 15 years of age. This is the first study to clarify the true prevalence of permanent CH in Japan. View Full-Text
Keywords: congenital hypothyroidism; newborn screening; Japan; re-evaluations; prevalence congenital hypothyroidism; newborn screening; Japan; re-evaluations; prevalence
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MDPI and ACS Style

Nagasaki, K.; Sato, H.; Sasaki, S.; Nyuzuki, H.; Shibata, N.; Sawano, K.; Hiroshima, S.; Asami, T. Re-Evaluation of the Prevalence of Permanent Congenital Hypothyroidism in Niigata, Japan: A Retrospective Study. Int. J. Neonatal Screen. 2021, 7, 27. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020027

AMA Style

Nagasaki K, Sato H, Sasaki S, Nyuzuki H, Shibata N, Sawano K, Hiroshima S, Asami T. Re-Evaluation of the Prevalence of Permanent Congenital Hypothyroidism in Niigata, Japan: A Retrospective Study. International Journal of Neonatal Screening. 2021; 7(2):27. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020027

Chicago/Turabian Style

Nagasaki, Keisuke, Hidetoshi Sato, Sunao Sasaki, Hiromi Nyuzuki, Nao Shibata, Kentaro Sawano, Shota Hiroshima, and Tadashi Asami. 2021. "Re-Evaluation of the Prevalence of Permanent Congenital Hypothyroidism in Niigata, Japan: A Retrospective Study" International Journal of Neonatal Screening 7, no. 2: 27. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020027

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