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First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia

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Department of Pediatrics, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia
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Department of Pediatrics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan
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Department of Health Promotion and Disease Prevention, National Center for Public Health, Ulaanbaatar 13381, Mongolia
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Children’s Hospital, National Center for Maternal and Child Health, Bayangol District, Ulaanbaatar 16060, Mongolia
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Screening Diagnostic Reference Center, Bayangol District, Ulaanbaatar 16091, Mongolia
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Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia
*
Author to whom correspondence should be addressed.
Academic Editor: Natasha Heather
Int. J. Neonatal Screen. 2021, 7(2), 29; https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020029
Received: 2 May 2021 / Revised: 26 May 2021 / Accepted: 3 June 2021 / Published: 7 June 2021
Congenital hypothyroidism (CH) is among the most common conditions leading to intellectual disability, which can be prevented by early detection through newborn screening (NBS). In Mongolia, a regional screening program for CH was launched in 2000, which was supported by the International Atomic Energy Agency (IAEA) for the Asia Pacific Region. In our present study, a total of 23,002 newborns from nine districts in Ulaanbaatar were screened between 2012 and 2020, by the measurement of the thyroid-stimulating hormone (TSH) from dried blood spots, sampled 24 to 72 h after birth. The level of TSH was measured by the DELFIA assay. The overall CH prevalence confirmed at birth was 1/2091. The female-to-male ratio for CH cases was 1.8:1. The majority of patients were asymptomatic (72.7% of CH cases); umbilical hernia and cold or mottled skin were reported symptoms in patients with CH (27.3%). Thyroid dysgenesis (hypoplasia and agenesis) was the most common etiology, with a total of nine cases (81.8%) out of the eleven patients. The lapse between the birth date and the initiation of L-thyroxine treatment in CH-positive children was lower than 15 days in 63.64% of cases or 15 to 30 days in 36.36% of children. Further research is required to expand the screening coverage for CH in Mongolia. View Full-Text
Keywords: congenital hypothyroidism; neonatal screening; blood spot test; filter paper congenital hypothyroidism; neonatal screening; blood spot test; filter paper
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MDPI and ACS Style

Tsevgee, A.; Batjargal, K.; Munkhchuluun, T.; Khurelbaatar, N.; Nansal, G.; Bulgan, O.-E.; Nyamjav, S.; Zagd, G.; Ganbaatar, E. First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia. Int. J. Neonatal Screen. 2021, 7, 29. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020029

AMA Style

Tsevgee A, Batjargal K, Munkhchuluun T, Khurelbaatar N, Nansal G, Bulgan O-E, Nyamjav S, Zagd G, Ganbaatar E. First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia. International Journal of Neonatal Screening. 2021; 7(2):29. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020029

Chicago/Turabian Style

Tsevgee, Altantuya, Khishigjargal Batjargal, Tsolmon Munkhchuluun, Naranchimeg Khurelbaatar, Gerelmaa Nansal, Oyun-Erdene Bulgan, Sumberzul Nyamjav, Gerelmaa Zagd, and Erdenetuya Ganbaatar. 2021. "First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia" International Journal of Neonatal Screening 7, no. 2: 29. https://0-doi-org.brum.beds.ac.uk/10.3390/ijns7020029

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