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First Experiences with Newborn Screening for Congenital Hypothyroidism in Ulaanbaatar, Mongolia

Successful Implementation of Newborn Screening for Hemoglobin Disorders in the Philippines

Newborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines
Department of Pediatrics, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines
National Newborn Screening and Global Resource Center, Austin, TX 78759, USA
University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Newborn Screening Center—Mindanao, Southern Philippine Medical Center, Davao 8000, Philippines
Newborn Screening Center—Visayas, West Visayas State University Medical Center, Iloilo City 5000, Philippines
Newborn Screening Center—Southern Luzon, Daniel O. Mercado Medical Center, Tanauan City 4232, Philippines
Newborn Screening Center—National Institutes of Health, Quezon City 1101, Philippines
Newborn Screening Center—Central Luzon, Angeles City University Foundation Medical Center, Angeles City 2009, Philippines
Newborn Center—Northern Luzon, Mariano Marcos Memorial Hospital and Medical Center, Batac City 2906, Philippines
UCSF Benioff Children’s Hospital Oakland, Oakland, CA 94609, USA
Global Blood Therapeutics, Inc., South San Francisco, CA 94080, USA
Author to whom correspondence should be addressed.
Academic Editor: Stephan Lobitz
Int. J. Neonatal Screen. 2021, 7(2), 30;
Received: 21 April 2021 / Revised: 8 June 2021 / Accepted: 10 June 2021 / Published: 17 June 2021
The Philippine newborn bloodspot screening (NBS) program began in 1996 with 24 hospitals and was formalized by legislation in 2004. The NBS panel was recently expanded to include a number of additional hereditary congenital conditions. Expertise and experiences from other NBS programs already screening for hemoglobinopathies were essential to its successful integration into the ongoing dried bloodspot NBS program in the Philippines. Building on clinical experiences and population data from Filipinos born in California, USA, hemoglobinopathies (including thalassemias) were selected for inclusion in the expanded screening panel. Hemoglobinopathy NBS, using high performance liquid chromatography, was implemented in a stepwise manner into the seven regional NBS screening laboratories. A central university laboratory provides confirmatory testing using both capillary electrophoresis and molecular methodologies. NBS results indicating carriers are followed up with educational fact sheets, while results of presumptive disease are referred for confirmatory testing and follow-up with a hematologist. Long-term care is provided through newborn screening continuity clinics across the country. Hemoglobinopathy NBS is now included in the national insurance package and screening uptake continues to increase nationally, exceeding 90% of all newborns in 7400+ hospitals and birthing centers nationwide prior to the COVID-19 pandemic. View Full-Text
Keywords: newborn screening; thalassemia; hemoglobinopathy; HPLC; Philippines newborn screening; thalassemia; hemoglobinopathy; HPLC; Philippines
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MDPI and ACS Style

Padilla, C.D.; Therrell, B.L., Jr.; Alcausin, M.M.L.B.; de Castro, R.C., Jr.; Gepte, M.B.P.; Reyes, M.E.L.; Jomento, C.M.; Suarez, R.C.N.; Maceda, E.B.G.; Abarquez, C.G.; Posecion, J.E.W.C.; Andal, A.P.; Elizaga, A.L.G.; Halili-Mendoza, B.C.; Otayza, M.P.V.K.; Hoppe, C.C. Successful Implementation of Newborn Screening for Hemoglobin Disorders in the Philippines. Int. J. Neonatal Screen. 2021, 7, 30.

AMA Style

Padilla CD, Therrell BL Jr., Alcausin MMLB, de Castro RC Jr., Gepte MBP, Reyes MEL, Jomento CM, Suarez RCN, Maceda EBG, Abarquez CG, Posecion JEWC, Andal AP, Elizaga ALG, Halili-Mendoza BC, Otayza MPVK, Hoppe CC. Successful Implementation of Newborn Screening for Hemoglobin Disorders in the Philippines. International Journal of Neonatal Screening. 2021; 7(2):30.

Chicago/Turabian Style

Padilla, Carmencita D., Bradford L. Therrell Jr., Maria M.L.B. Alcausin, Reynaldo C. de Castro Jr., Maria B.P. Gepte, Ma. E.L. Reyes, Charity M. Jomento, Riza C.N. Suarez, Ebner B.G. Maceda, Conchita G. Abarquez, J. E.W.C. Posecion, Alma P. Andal, Anna L.G. Elizaga, Bernadette C. Halili-Mendoza, Maria P.V.K. Otayza, and Carolyn C. Hoppe 2021. "Successful Implementation of Newborn Screening for Hemoglobin Disorders in the Philippines" International Journal of Neonatal Screening 7, no. 2: 30.

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