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Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages

1
Biodiversity and Biotechnology Network of the Legal Amazon, Adrianópolis Manaus 69057-070, AM. CEP, Brazil
2
Laboratory of Neurosciences and Behavior, Institute for Health and Biological Studies, Federal University of the South and Southeast of Pará, Marabá 68507-670, PA, s/ CEP, Brazil
3
Faculty of Psychology, Institute for Health and Biological Studies, Federal University of the South and Southeast of Pará, Marabá 68507-670, PA, s/ CEP, Brazil
4
Laboratory of Neuropharmacology and Biophysics, Center for Biological and Health Sciences, Pará State University, Marabá 68507-670, PA, CEP, Brazil
*
Author to whom correspondence should be addressed.
Received: 19 September 2019 / Revised: 28 July 2020 / Accepted: 28 July 2020 / Published: 31 July 2020
(This article belongs to the Special Issue Fish as Model Organisms for (Eco)Toxicology and Disease)
The industry is increasingly relying on fish for toxicity assessment. However, current guidelines for toxicity assessment focus on teratogenicity and mortality. From an ecotoxicological point of view, however, these endpoints may not reflect the “full picture” of possible deleterious effects that can nonetheless result in decreased fitness and/or inability to adapt to a changing environment, affecting whole populations. Therefore, assessing sublethal effects add relevant data covering different aspects of toxicity at different levels of analysis. The impacts of toxicants on neurobehavioral function have the potential to affect many different life-history traits, and are easier to assess in the laboratory than in the wild. We propose that carefully-controlled laboratory experiments on different behavioral domains—including anxiety, aggression, and exploration—can increase our understanding of the ecotoxicological impacts of contaminants, since these domains are related to traits such as defense, sociality, and reproduction, directly impacting life-history traits. The effects of selected contaminants on these tests are reviewed, focusing on larval and adult zebrafish, showing that these behavioral domains are highly sensitive to small concentrations of these substances. These strategies suggest a way forward on ecotoxicological research using fish. View Full-Text
Keywords: neurobehavioral assessment; ecotoxicology; zebrafish; neurotoxicology neurobehavioral assessment; ecotoxicology; zebrafish; neurotoxicology
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MDPI and ACS Style

Dutra Costa, B.P.; Aquino Moura, L.; Gomes Pinto, S.A.; Lima-Maximino, M.; Maximino, C. Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages. Fishes 2020, 5, 23. https://0-doi-org.brum.beds.ac.uk/10.3390/fishes5030023

AMA Style

Dutra Costa BP, Aquino Moura L, Gomes Pinto SA, Lima-Maximino M, Maximino C. Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages. Fishes. 2020; 5(3):23. https://0-doi-org.brum.beds.ac.uk/10.3390/fishes5030023

Chicago/Turabian Style

Dutra Costa, Bruna P., Layana Aquino Moura, Sabrina A. Gomes Pinto, Monica Lima-Maximino, and Caio Maximino. 2020. "Zebrafish Models in Neural and Behavioral Toxicology across the Life Stages" Fishes 5, no. 3: 23. https://0-doi-org.brum.beds.ac.uk/10.3390/fishes5030023

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