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Central Precocious Puberty in Boys and Girls: Similarities and Differences

Pediatric and Adolescent Endocrinology, Division of Paediatrics, Azienda Ospedaliero-Universitaria Pisana, IT-56126 Pisa, Italy
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Received: 3 February 2021 / Revised: 27 February 2021 / Accepted: 5 March 2021 / Published: 15 March 2021
Central precocious puberty (CPP) is due to the premature activation of the hypothalamic–pituitary–gonadal axis, which is responsible for the appearance of secondary sexual characteristics. It occurs before the age of 8 and 9 in girls and boys, respectively. CPP shows higher incidence in females than in males. Causes of CPP are similar in both sexes, but the idiopathic form is more frequent in girls, while organic forms are more frequent in males. Recent studies demonstrated a role of some genetic variants in the pathogenesis of CPP. The diagnostic evaluation based on accurate physical examination, assessment of the pituitary–gonadal axis, pelvic sonography in girls, and determination of bone age. Magnetic resonance of the central nervous system should be done in all boys and selected girls. Since the 1980s, pharmacologic treatment involves the use of gonadotropin-releasing hormone (GnRH) analogs. These drugs are characterized by few side effects and long-term safety. Many data are available on the outcome of GnRH analog treated female patients, while poor data are reported in boys. Adult height is improved in both sexes. View Full-Text
Keywords: central precocious puberty; girls; boys; GnRH analog; adult height; fertility central precocious puberty; girls; boys; GnRH analog; adult height; fertility
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MDPI and ACS Style

Mucaria, C.; Tyutyusheva, N.; Baroncelli, G.I.; Peroni, D.; Bertelloni, S. Central Precocious Puberty in Boys and Girls: Similarities and Differences. Sexes 2021, 2, 119-131. https://0-doi-org.brum.beds.ac.uk/10.3390/sexes2010010

AMA Style

Mucaria C, Tyutyusheva N, Baroncelli GI, Peroni D, Bertelloni S. Central Precocious Puberty in Boys and Girls: Similarities and Differences. Sexes. 2021; 2(1):119-131. https://0-doi-org.brum.beds.ac.uk/10.3390/sexes2010010

Chicago/Turabian Style

Mucaria, Cristina, Nina Tyutyusheva, Giampiero I. Baroncelli, Diego Peroni, and Silvano Bertelloni. 2021. "Central Precocious Puberty in Boys and Girls: Similarities and Differences" Sexes 2, no. 1: 119-131. https://0-doi-org.brum.beds.ac.uk/10.3390/sexes2010010

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