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Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG)

Institute of Neurology, Medical University Vienna, AKH 4J, A-1090 Vienna, Austria
Received: 9 October 2018 / Revised: 19 October 2018 / Accepted: 22 October 2018 / Published: 29 October 2018
Aging-related tau astrogliopathy (ARTAG) is an umbrella term that encompasses a spectrum of morphological abnormalities seen in astrocytes of the aging brain using immunostaining for pathological forms of the microtubule-associated protein tau. Morphologies of ARTAG include thorn-shaped astrocytes (TSA), and additionally granular/fuzzy astrocytes (GFA) characterized by fine granular tau immunoreactivity extending into the astrocytic processes. Thorn-shaped astrocytes can be present in the same brain in subpial, subependymal, perivascular, and white and gray matter locations together with GFAs, which are seen in the gray matter. Primary tauopathies show ARTAG-related morphologies as well, moreover, GFA has been proposed to present a conceptual link between brain ageing and primary tauopathies. Sequential distribution patterns have been recognized for subpial, white and gray matter ARTAG. This either suggests the involvement of astrocytes in the propagation of tau pathology or reflects the consequence of a long-term pathogenic process such as barrier dysfunction, local mechanical impact, or early response to neuronal degeneration. The concept of ARTAG facilitated communication among neuropathologists and researchers, informed biomarker researchers with focus on tau-related indicators and motivated further exploration of the significance of astrocytic lesions in various neurodegenerative conditions. View Full-Text
Keywords: aging-related tau astrogliopathy (ARTAG); aging-related tau astrogliopathy; astroglia; barrier; neurodegenerative disease; protein-astrogliopathy; protein astrogliopathy (PAG); tau aging-related tau astrogliopathy (ARTAG); aging-related tau astrogliopathy; astroglia; barrier; neurodegenerative disease; protein-astrogliopathy; protein astrogliopathy (PAG); tau
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MDPI and ACS Style

Kovacs, G.G. Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG). Neuroglia 2018, 1, 339-350. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020023

AMA Style

Kovacs GG. Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG). Neuroglia. 2018; 1(2):339-350. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020023

Chicago/Turabian Style

Kovacs, Gabor G. 2018. "Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG)" Neuroglia 1, no. 2: 339-350. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020023

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