Next Article in Journal
Putative Receptors Underpinning l-Lactate Signalling in Locus Coeruleus
Previous Article in Journal
Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG)
Article

Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part III: Oligodendrocyte and Myelin

1
Diabetes and Cardiovascular Center, University of Missouri School of Medicine, Columbia, MO 65212, USA
2
Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, MO 63212, USA
3
Electron Microscopy Core Facility, University of Missouri, Columbia, MO 65211, USA
4
Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65212, USA
5
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
*
Author to whom correspondence should be addressed.
Received: 9 October 2018 / Revised: 31 October 2018 / Accepted: 5 November 2018 / Published: 8 November 2018
Obesity, insulin resistance, and type 2 diabetes mellitus are associated with diabetic cognopathy. In this study, we tested the hypothesis that neurovascular unit(s) (NVU), oligodendrocytes, and myelin within cerebral cortical grey matter and deeper transitional zone regions between the cortical grey matter and white matter may be abnormal. The monogenic (Leprdb) female diabetic db/db [BKS.CgDock7m +/+ Leprdb/J] (DBC) mouse model was utilized for this ultrastructural study. Upon sacrifice (20 weeks of age), left-brain hemispheres of the DBC and age-matched non-diabetic wild type control C57BL/KsJ (CKC) mice were immediately immersion-fixed. We found prominent remodeling of oligodendrocytes with increased nuclear chromatin condensation and volume and increased numbers of active myelination sites of the cytoplasm in transition zones. Marked dysmyelination with outer myelin lamellae sheath splitting, separation, and ballooning with aberrant mitochondria in grey matter and similar myelin remodeling changes with marked disarray with additional axonal collapse in transitional zones in DBC as compared to CKC models. View Full-Text
Keywords: db/db mouse model; myelin; neurovascular unit; oligodendrocyte; subcortical white matter; type 2 diabetes db/db mouse model; myelin; neurovascular unit; oligodendrocyte; subcortical white matter; type 2 diabetes
Show Figures

Figure 1

MDPI and ACS Style

Hayden, M.R.; Grant, D.G.; Aroor, A.; DeMarco, V.G. Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part III: Oligodendrocyte and Myelin. Neuroglia 2018, 1, 351-364. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020024

AMA Style

Hayden MR, Grant DG, Aroor A, DeMarco VG. Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part III: Oligodendrocyte and Myelin. Neuroglia. 2018; 1(2):351-364. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020024

Chicago/Turabian Style

Hayden, Melvin R.; Grant, Deana G.; Aroor, Aranyra; DeMarco, Vincent G. 2018. "Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part III: Oligodendrocyte and Myelin" Neuroglia 1, no. 2: 351-364. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia1020024

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop