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Neurovascular Coupling in Seizures

1
Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
2
Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jessica Filosa
Received: 31 August 2021 / Revised: 1 October 2021 / Accepted: 5 October 2021 / Published: 11 October 2021
(This article belongs to the Special Issue Dynamic Vascular-Glial-Neuronal Interactions in Health and Disease)
Neurovascular coupling is a key control mechanism in cerebral blood flow (CBF) regulation. Importantly, this process was demonstrated to be affected in several neurological disorders, including epilepsy. Neurovascular coupling (NVC) is the basis for functional brain imaging, such as PET, SPECT, fMRI, and fNIRS, to assess and map neuronal activity, thus understanding NVC is critical to properly interpret functional imaging signals. However, hemodynamics, as assessed by these functional imaging techniques, continue to be used as a surrogate to map seizure activity; studies of NVC and cerebral blood flow control during and following seizures are rare. Recent studies have provided conflicting results, with some studies showing focal increases in CBF at the onset of a seizure while others show decreases. In this brief review article, we provide an overview of the current knowledge state of neurovascular coupling and discuss seizure-related alterations in neurovascular coupling and CBF control. View Full-Text
Keywords: neurovascular coupling; seizures; cerebral blood flow; astrocytes; calcium; oxygen; epilepsy; penetrating arterioles; capillaries; pericytes neurovascular coupling; seizures; cerebral blood flow; astrocytes; calcium; oxygen; epilepsy; penetrating arterioles; capillaries; pericytes
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MDPI and ACS Style

Teskey, G.C.; Tran, C.H.T. Neurovascular Coupling in Seizures. Neuroglia 2021, 2, 36-47. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia2010005

AMA Style

Teskey GC, Tran CHT. Neurovascular Coupling in Seizures. Neuroglia. 2021; 2(1):36-47. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia2010005

Chicago/Turabian Style

Teskey, G. C., and Cam H.T. Tran 2021. "Neurovascular Coupling in Seizures" Neuroglia 2, no. 1: 36-47. https://0-doi-org.brum.beds.ac.uk/10.3390/neuroglia2010005

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