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Review
Peer-Review Record

Immunomodulatory Effects of TGF-β Family Signaling within Intestinal Epithelial Cells and Carcinomas

Gastrointest. Disord. 2019, 1(2), 290-300; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord1020024
by Paula Marincola Smith 1,*, Anna L. Means 1,2 and R. Daniel Beauchamp 1,2
Reviewer 1:
Reviewer 2: Anonymous
Gastrointest. Disord. 2019, 1(2), 290-300; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord1020024
Submission received: 4 June 2019 / Revised: 18 June 2019 / Accepted: 21 June 2019 / Published: 25 June 2019

Round 1

Reviewer 1 Report

A very nice review by Smith, et al.   


Please expand on the non-SMAD signlaing molecular that act as the effector molecules for non-SMAD activity. This is especially in the context of metastatic disease.  This is not fully described in the literature but worthy of a bit more analysis in this review article.

Please get into a little more detail regarding the role of TGF-beta in inducing changes to immune cells- activity of NK cells, T cells, etc. as well as polarization of macrophages.  This is a critically important TME context.

Author Response

Please see attached file.

Author Response File: Author Response.docx

Reviewer 2 Report

Dear Editor,

Gastrointetinal disorders

 

 

 

 The authors discribed detailed TGF-b sinlaling in leukocytes and intestinal epithelial cells. This review is well written, and especially Smad7 knockdown therapy for Crohn’s disease is very immpressive. I think this paper is good for publication in the present form.

 

 

Overall recommendation: 

 Good for publish in the present form.




Author Response

Please see attached file.

Author Response File: Author Response.docx

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